| Title |
Impedimetric detection of cocaine by using an aptamer attached to a screen printed electrode modified with a dendrimer/silver nanoparticle nanocomposite
|
|---|---|
| Published in |
Microchimica Acta, March 2018
|
| DOI | 10.1007/s00604-018-2709-6 |
| Pubmed ID | |
| Authors |
Mahmoud Roushani, Faezeh Shahdost-fard |
| Abstract |
The authors describe a highly sensitive method for the aptamer (Apt) based impedimetric determination of cocaine. The surface of a screen-printed electrode (SPE) was modified with a nanocomposite of dendrimer and silver nanoparticles (AgNPs). The cocaine-binding Apt was attached to a dendrimer/AgNP/SPE surface, forming a sensitive layer for the determination of cocaine. The incubation with the analyte resulted in the formation of a cocaine/Apt complex on the electrode surface. As a consequence, folding and conformational change in the aptamer structure was induced, this resulting in a change in the impedimetric signal. The aptaassay exhibits highly efficient sensing characteristics with a good linearity of 1 fmol L-1 to 100 nmol L-1 (with two linear ranges) and a limit of detection (LOD) of 333 amol L-1. Its excellent specificity and high sensitivity suggest that this kind of aptamer-based assay may be applied to detect other targets in this field. Graphical Abstract Designing of an aptaassay via immobilization of a functionalized aptamer with silver nanoparticle (AgNPs-Apt) on the modified screen-printed electrode (SPE) with dendrimer/silver nanoparticle nanocomposite (Den-AgNPs) for impedimetric detection of cocaine. |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 19% |
| Student > Master | 6 | 17% |
| Student > Bachelor | 2 | 6% |
| Researcher | 2 | 6% |
| Other | 2 | 6% |
| Other | 4 | 11% |
| Unknown | 13 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 11 | 31% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Engineering | 2 | 6% |
| Materials Science | 2 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Other | 4 | 11% |
| Unknown | 13 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2022.
All research outputs
#8,176,636
of 25,220,525 outputs
Outputs from Microchimica Acta
#213
of 1,524 outputs
Outputs of similar age
#132,152
of 338,926 outputs
Outputs of similar age from Microchimica Acta
#2
of 39 outputs
Altmetric has tracked 25,220,525 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 1,524 research outputs from this source. They receive a mean Attention Score of 2.5. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,926 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.