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Mendeley readers
Attention Score in Context
| Title |
Enzymatic Chemoselective Aldehyde–Ketone Cross‐Couplings through the Polarity Reversal of Methylacetoin
|
|---|---|
| Published in |
Angewandte Chemie. International Edition, April 2015
|
| DOI | 10.1002/anie.201502102 |
| Pubmed ID | |
| Authors |
Giovanni Bernacchia, Olga Bortolini, Morena De Bastiani, Lindomar Alberto Lerin, Sabrina Loschonsky, Alessandro Massi, Michael Müller, Pier Paolo Giovannini |
| Abstract |
The thiamine diphosphate (ThDP) dependent enzyme acetoin:dichlorophenolindophenol oxidoreductase (Ao:DCPIP OR) from Bacillus licheniformis was cloned and overexpressed in Escherichia coli. The recombinant enzyme shared close similarities with the acetylacetoin synthase (AAS) partially purified from Bacillus licheniformis suggesting that they could be the same enzyme. The product scope of the recombinant Ao:DCPIP OR was expanded to chiral tertiary α-hydroxy ketones through the rare aldehyde-ketone cross-carboligation reaction. Unprecedented is the use of methylacetoin as the acetyl anion donor in combination with a range of strongly to weakly activated ketones. In some cases, Ao:DCPIP OR produced the desired tertiary alcohols with stereochemistry opposite to that obtained with other ThDP-dependent enzymes. The combination of methylacetoin as acyl anion synthon and novel ThDP-dependent enzymes considerably expands the available range of CC bond formations in asymmetric synthesis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 23% |
| Researcher | 7 | 18% |
| Student > Master | 5 | 13% |
| Professor > Associate Professor | 4 | 10% |
| Professor | 3 | 8% |
| Other | 2 | 5% |
| Unknown | 10 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 17 | 43% |
| Biochemistry, Genetics and Molecular Biology | 4 | 10% |
| Chemical Engineering | 3 | 8% |
| Agricultural and Biological Sciences | 2 | 5% |
| Mathematics | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 11 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2015.
All research outputs
#22,759,452
of 25,373,627 outputs
Outputs from Angewandte Chemie. International Edition
#45,801
of 49,991 outputs
Outputs of similar age
#240,369
of 279,958 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#589
of 675 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 49,991 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,958 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 675 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.