You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Current kinase inhibitors cover a tiny fraction of fragment space
|
|---|---|
| Published in |
Bioorganic & Medicinal Chemistry Letters, April 2015
|
| DOI | 10.1016/j.bmcl.2015.04.005 |
| Pubmed ID | |
| Authors |
Hongtao Zhao, Amedeo Caflisch |
| Abstract |
We analyze the chemical space coverage of kinase inhibitors in the public domain from a fragment point of view. A set of 26,668 kinase inhibitors from the ChEMBL database of bioactive molecules were decomposed automatically by fragmentation at rotatable bonds. Remarkably, about half of the resulting 10,302 fragments originate from inaccessible libraries, as they are not present in commercially available compounds. By mapping to the established kinase pharmacophore models, privileged fragments in sub-pockets are identified, for example, the 5681 ring-containing fragments capable of forming bi-dentate hydrogen bonds with the hinge region in the ATP binding site. Surprisingly, hinge-binding fragments in current kinase inhibitors cover only 1% of the potential hinge-binders obtained by decomposing a library of nearly 7.5million commercially available compounds, which indicates that a large fraction of chemical space is unexplored. |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 3% |
| Unknown | 39 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 35% |
| Student > Ph. D. Student | 8 | 20% |
| Professor | 4 | 10% |
| Professor > Associate Professor | 4 | 10% |
| Student > Doctoral Student | 3 | 8% |
| Other | 4 | 10% |
| Unknown | 3 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 21 | 53% |
| Agricultural and Biological Sciences | 7 | 18% |
| Computer Science | 2 | 5% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Psychology | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 5 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2015.
All research outputs
#4,807,882
of 25,374,647 outputs
Outputs from Bioorganic & Medicinal Chemistry Letters
#2,213
of 13,778 outputs
Outputs of similar age
#56,558
of 278,951 outputs
Outputs of similar age from Bioorganic & Medicinal Chemistry Letters
#16
of 121 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,778 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,951 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.