| Title |
In vitro release behavior and cytotoxicity of doxorubicin-loaded gold nanoparticles in cancerous cells
|
|---|---|
| Published in |
Biotechnology Techniques, February 2010
|
| DOI | 10.1007/s10529-010-0208-x |
| Pubmed ID | |
| Authors |
B. Asadishad, M. Vossoughi, I. Alamzadeh |
| Abstract |
Doxorubicin (DOX), a common cancer chemotherapeutics, was conjugated to folate-modified thiolated-polyethylene glycol-functionalized gold nanoparticles. The in vitro, controlled release behavior of DOX-loaded gold nanoparticles was observed using porous dialysis membranes (cut-off = 2 kDa). DOX-loaded gold nanoparticles had higher cytotoxicity for folate-receptor-positive cells (KB cells) compared to folate-receptor-negative cells (A549 cells) which were 48 and 62% viable for 10 microM doxorubicin, respectively. This indicates the potential of these nano-carriers for targeted-delivery. In addition, healthy cell viability was 69% for 10 microM free doxorubicin whereas for the same content of drug in DOX-loaded nanoparticles healthy cell viability increased to 80%. |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 2% |
| Italy | 1 | 2% |
| Brazil | 1 | 2% |
| United Kingdom | 1 | 2% |
| Spain | 1 | 2% |
| Unknown | 38 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 28% |
| Student > Master | 7 | 16% |
| Researcher | 6 | 14% |
| Professor | 3 | 7% |
| Student > Postgraduate | 3 | 7% |
| Other | 6 | 14% |
| Unknown | 6 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 14 | 33% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 12% |
| Engineering | 4 | 9% |
| Materials Science | 4 | 9% |
| Medicine and Dentistry | 3 | 7% |
| Other | 5 | 12% |
| Unknown | 8 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2016.
All research outputs
#8,535,472
of 25,374,647 outputs
Outputs from Biotechnology Techniques
#827
of 2,762 outputs
Outputs of similar age
#51,427
of 172,974 outputs
Outputs of similar age from Biotechnology Techniques
#6
of 18 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,762 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
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We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.