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Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation

Overview of attention for article published in Nature Communications, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

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1 news outlet
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10 X users

Citations

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88 Dimensions

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132 Mendeley
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Title
Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation
Published in
Nature Communications, April 2015
DOI 10.1038/ncomms7840
Pubmed ID
Authors

Marianna Papaspyridonos, Irina Matei, Yujie Huang, Maria do Rosario Andre, Helene Brazier-Mitouart, Janelle C. Waite, April S. Chan, Julie Kalter, Ilyssa Ramos, Qi Wu, Caitlin Williams, Jedd D. Wolchok, Paul B. Chapman, Hector Peinado, Niroshana Anandasabapathy, Allyson J. Ocean, Rosandra N. Kaplan, Jeffrey P. Greenfield, Jacqueline Bromberg, Dimitris Skokos, David Lyden

Abstract

A central mechanism of tumour progression and metastasis involves the generation of an immunosuppressive 'macroenvironment' mediated in part through tumour-secreted factors. Here we demonstrate that upregulation of the Inhibitor of Differentiation 1 (Id1), in response to tumour-derived factors, such as TGFβ, is responsible for the switch from dendritic cell (DC) differentiation to myeloid-derived suppressor cell expansion during tumour progression. Genetic inactivation of Id1 largely corrects the myeloid imbalance, whereas Id1 overexpression in the absence of tumour-derived factors re-creates it. Id1 overexpression leads to systemic immunosuppression by downregulation of key molecules involved in DC differentiation and suppression of CD8 T-cell proliferation, thus promoting primary tumour growth and metastatic progression. Furthermore, advanced melanoma patients have increased plasma TGFβ levels and express higher levels of ID1 in myeloid peripheral blood cells. This study reveals a critical role for Id1 in suppressing the anti-tumour immune response during tumour progression and metastasis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
Germany 1 <1%
United Kingdom 1 <1%
Denmark 1 <1%
Luxembourg 1 <1%
Unknown 127 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 18%
Student > Master 23 17%
Researcher 19 14%
Student > Bachelor 10 8%
Student > Doctoral Student 6 5%
Other 22 17%
Unknown 28 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 26 20%
Agricultural and Biological Sciences 25 19%
Medicine and Dentistry 19 14%
Immunology and Microbiology 12 9%
Neuroscience 2 2%
Other 14 11%
Unknown 34 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2015.
All research outputs
#2,229,404
of 23,923,788 outputs
Outputs from Nature Communications
#25,866
of 50,036 outputs
Outputs of similar age
#29,099
of 267,233 outputs
Outputs of similar age from Nature Communications
#290
of 724 outputs
Altmetric has tracked 23,923,788 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 50,036 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.2. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,233 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 724 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.