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Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy

Overview of attention for article published in Autophagy, April 2015
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  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

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1 Facebook page

Citations

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69 Mendeley
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Title
Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy
Published in
Autophagy, April 2015
DOI 10.1080/15548627.2015.1023984
Pubmed ID
Authors

Paul Hsu, Xiaolei Liu, Jun Zhang, Hong-Gang Wang, Ji-Ming Ye, Yuguang Shi

Abstract

Tafazzin (TAZ) is a phospholipid transacylase that catalyzes the remodeling of cardiolipin, a mitochondrial phospholipid required for oxidative phosphorylation. Mutations of TAZ cause Barth syndrome, which is characterized by mitochondrial dysfunction and dilated cardiomyopathy, leading to premature death. However, the molecular mechanisms underlying the cause of mitochondrial dysfunction in Barth syndrome remain poorly understood. Here we investigated the role of TAZ in regulating mitochondrial function and mitophagy. Using primary mouse embryonic fibroblasts (MEFs) with doxycycline-inducible knockdown of Taz, we showed that TAZ deficiency in MEFs caused defective mitophagosome biogenesis, but not other autophagic processes. Consistent with a key role of mitophagy in mitochondria quality control, TAZ deficiency in MEFs also led to impaired oxidative phosphorylation and severe oxidative stress. Together, these findings provide key insights on mitochondrial dysfunction in Barth syndrome, suggesting that pharmacological restoration of mitophagy may provide a novel treatment for this lethal condition.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 3%
Unknown 67 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 20%
Researcher 8 12%
Student > Master 7 10%
Student > Bachelor 6 9%
Student > Doctoral Student 5 7%
Other 13 19%
Unknown 16 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 23 33%
Agricultural and Biological Sciences 13 19%
Medicine and Dentistry 4 6%
Neuroscience 3 4%
Nursing and Health Professions 2 3%
Other 6 9%
Unknown 18 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2015.
All research outputs
#14,222,419
of 22,800,560 outputs
Outputs from Autophagy
#1,301
of 2,454 outputs
Outputs of similar age
#138,852
of 264,516 outputs
Outputs of similar age from Autophagy
#13
of 52 outputs
Altmetric has tracked 22,800,560 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,454 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,516 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.