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X Demographics
Mendeley readers
Attention Score in Context
| Title |
KRAS as a Therapeutic Target
|
|---|---|
| Published in |
Clinical Cancer Research, April 2015
|
| DOI | 10.1158/1078-0432.ccr-14-2662 |
| Pubmed ID | |
| Authors |
Frank McCormick |
| Abstract |
KRAS proteins play a major role in human cancer, but have not yielded to therapeutic attack. New technologies in drug discovery and insights into signaling pathways that KRAS controls have promoted renewed efforts to develop therapies through direct targeting of KRAS itself, new ways of blocking KRAS processing, or by identifying targets that KRAS cancers depend on for survival. Although drugs that block the well-established downstream pathways, RAF-MAPK and PI3K, are being tested in the clinic, new efforts are under way to exploit previously unrecognized vulnerabilities, such as altered metabolic networks, or novel pathways identified through synthetic lethal screens. Furthermore, new ways of suppressing KRAS gene expression and of harnessing the immune system offer further hope that new ways of treating KRAS are finally coming into view. These issues are discussed in this edition of CCR Focus. Clin Cancer Res; 21(8); 1797-801. ©2015 AACR. See all articles in this CCR Focus section, "Targeting RAS-Driven Cancers." |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 357 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| United Kingdom | 1 | <1% |
| Germany | 1 | <1% |
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 350 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 73 | 20% |
| Student > Ph. D. Student | 68 | 19% |
| Student > Bachelor | 51 | 14% |
| Student > Master | 29 | 8% |
| Student > Doctoral Student | 22 | 6% |
| Other | 48 | 13% |
| Unknown | 66 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 83 | 23% |
| Agricultural and Biological Sciences | 76 | 21% |
| Medicine and Dentistry | 46 | 13% |
| Chemistry | 23 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 22 | 6% |
| Other | 32 | 9% |
| Unknown | 75 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2023.
All research outputs
#1,502,697
of 24,498,639 outputs
Outputs from Clinical Cancer Research
#1,072
of 13,028 outputs
Outputs of similar age
#19,425
of 268,883 outputs
Outputs of similar age from Clinical Cancer Research
#16
of 187 outputs
Altmetric has tracked 24,498,639 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,028 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,883 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 187 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.