| Title |
Efficacy of perioperative synbiotics treatment for the prevention of surgical site infection after laparoscopic colorectal surgery: a randomized controlled trial
|
|---|---|
| Published in |
Surgery Today, May 2015
|
| DOI | 10.1007/s00595-015-1178-3 |
| Pubmed ID | |
| Authors |
Shunichiro Komatsu, Eiji Sakamoto, Shinji Norimizu, Yuji Shingu, Takashi Asahara, Koji Nomoto, Masato Nagino |
| Abstract |
The aim of this study was to assess the effect of perioperative oral administration of synbiotics on the surgical outcome in patients undergoing laparoscopic colorectal resection. In this single-center randomized, controlled trial, patients scheduled to undergo elective laparoscopic colorectal surgery were eligible to participate and randomly assigned to a synbiotics group or a control group. The primary study outcome was the development of infectious complications, particularly surgical site infection (SSI), within 30 days of surgery. In this study, 379 patients were enrolled and randomly assigned (173 to the synbiotics group and 206 to the control group), of whom 362 patients (168 to the synbiotics group and 194 to the control group) were eligible for this study. SSI occurred in 29 (17.3 %) patients in the synbiotics group and 44 (22.7 %) patients in the control group (OR: 0.761, 95 % CI 0.50-1.16; p = 0.20). Overall, the rate of postoperative complications, including anastomotic leakage, did not differ significantly between the two groups. Synbiotics treatment reversed the changes in fecal bacteria and organic acids after surgery and suppressed the increases in potentially pathogenic species, such as Clostridium difficile. The efficacy of perioperative administration of synbiotics was not validated as a treatment for reducing the incidence of infectious complications after laparoscopic colorectal resection. However, the microbial imbalance, in addition to the reduction in organic acids, could be improved by perioperative synbiotics treatment. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 105 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 17 | 16% |
| Researcher | 11 | 10% |
| Student > Master | 10 | 10% |
| Student > Ph. D. Student | 8 | 8% |
| Student > Bachelor | 8 | 8% |
| Other | 25 | 24% |
| Unknown | 26 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 30% |
| Nursing and Health Professions | 11 | 10% |
| Agricultural and Biological Sciences | 6 | 6% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Unspecified | 5 | 5% |
| Other | 14 | 13% |
| Unknown | 32 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2015.
All research outputs
#20,271,607
of 22,803,211 outputs
Outputs from Surgery Today
#666
of 992 outputs
Outputs of similar age
#222,706
of 264,373 outputs
Outputs of similar age from Surgery Today
#12
of 23 outputs
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