| Title |
DC-STAMP knock-down deregulates cytokine production and T-cell stimulatory capacity of LPS-matured dendritic cells
|
|---|---|
| Published in |
BMC Immunology, October 2011
|
| DOI | 10.1186/1471-2172-12-57 |
| Pubmed ID | |
| Authors |
Anna Sanecka, Marleen Ansems, Amy C Prosser, Katharina Danielski, Kathrin Warner, Martijn H den Brok, Bastiaan JH Jansen, Dagmar Eleveld-Trancikova, Gosse J Adema |
| Abstract |
Dendritic cells (DCs) are the highly specialized antigen presenting cells of the immune system that play a key role in regulating immune responses. DCs can efficiently initiate immune responses or induce tolerance. Due to this dual function, DCs are studied in the context of immunotherapy for both cancer and autoimmune diseases. Characterization of DC-specific genes, leading to better understanding of DC immunobiology, will help to guide their use in clinical settings. We previously identified DC-STAMP, a multi-membrane spanning protein preferentially expressed by DCs. DC-STAMP resides in the endoplasmic reticulum (ER) of immature DCs and translocates towards the Golgi compartment upon maturation. In this study we knocked down DC-STAMP in mouse bone marrow-derived DCs (mBMDCs) to determine its function. |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 4% |
| Unknown | 27 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 21% |
| Researcher | 6 | 21% |
| Student > Bachelor | 3 | 11% |
| Student > Doctoral Student | 2 | 7% |
| Other | 2 | 7% |
| Other | 6 | 21% |
| Unknown | 3 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 25% |
| Medicine and Dentistry | 7 | 25% |
| Immunology and Microbiology | 5 | 18% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Sports and Recreations | 2 | 7% |
| Other | 2 | 7% |
| Unknown | 3 | 11% |