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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The phototransduction machinery in the rod outer segment has a strong efficacy gradient
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, May 2015
|
| DOI | 10.1073/pnas.1423162112 |
| Pubmed ID | |
| Authors |
Monica Mazzolini, Giuseppe Facchetti, Laura Andolfi, Remo Proietti Zaccaria, Salvatore Tuccio, Johannes Treu, Claudio Altafini, Enzo M. Di Fabrizio, Marco Lazzarino, Gert Rapp, Vincent Torre |
| Abstract |
Rod photoreceptors consist of an outer segment (OS) and an inner segment. Inside the OS a biochemical machinery transforms the rhodopsin photoisomerization into electrical signal. This machinery has been treated as and is thought to be homogenous with marginal inhomogeneities. To verify this assumption, we developed a methodology based on special tapered optical fibers (TOFs) to deliver highly localized light stimulations. By using these TOFs, specific regions of the rod OS could be stimulated with spots of light highly confined in space. As the TOF is moved from the OS base toward its tip, the amplitude of saturating and single photon responses decreases, demonstrating that the efficacy of the transduction machinery is not uniform and is 5-10 times higher at the base than at the tip. This gradient of efficacy of the transduction machinery is attributed to a progressive depletion of the phosphodiesterase along the rod OS. Moreover we demonstrate that, using restricted spots of light, the duration of the photoresponse along the OS does not increase linearly with the light intensity as with diffuse light. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | 20% |
| United States | 1 | 20% |
| Norway | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Unknown | 34 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 20% |
| Student > Ph. D. Student | 6 | 17% |
| Student > Master | 5 | 14% |
| Other | 3 | 9% |
| Professor > Associate Professor | 3 | 9% |
| Other | 6 | 17% |
| Unknown | 5 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 23% |
| Neuroscience | 7 | 20% |
| Physics and Astronomy | 4 | 11% |
| Biochemistry, Genetics and Molecular Biology | 3 | 9% |
| Engineering | 3 | 9% |
| Other | 3 | 9% |
| Unknown | 7 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 53. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2023.
All research outputs
#756,664
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#12,600
of 101,438 outputs
Outputs of similar age
#9,146
of 269,260 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#178
of 935 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,260 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 935 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.