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Distinct Brainstem and Forebrain Circuits Receiving Tracheal Sensory Neuron Inputs Revealed Using a Novel Conditional Anterograde Transsynaptic Viral Tracing System

Overview of attention for article published in Journal of Neuroscience, May 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

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5 news outlets
blogs
1 blog
twitter
6 X users
patent
1 patent

Citations

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90 Dimensions

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96 Mendeley
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Title
Distinct Brainstem and Forebrain Circuits Receiving Tracheal Sensory Neuron Inputs Revealed Using a Novel Conditional Anterograde Transsynaptic Viral Tracing System
Published in
Journal of Neuroscience, May 2015
DOI 10.1523/jneurosci.5128-14.2015
Pubmed ID
Authors

Alice E. McGovern, Alexandria K. Driessen, David G. Simmons, Joseph Powell, Nicholas Davis-Poynter, Michael J. Farrell, Stuart B. Mazzone

Abstract

Sensory nerves innervating the mucosa of the airways monitor the local environment for the presence of irritant stimuli and, when activated, provide input to the nucleus of the solitary tract (Sol) and paratrigeminal nucleus (Pa5) in the medulla to drive a variety of protective behaviors. Accompanying these behaviors are perceivable sensations that, particularly for stimuli in the proximal end of the airways, can be discrete and localizable. Airway sensations likely reflect the ascending airway sensory circuitry relayed via the Sol and Pa5, which terminates broadly throughout the CNS. However, the relative contribution of the Sol and Pa5 to these ascending pathways is not known. In the present study, we developed and characterized a novel conditional anterograde transneuronal viral tracing system based on the H129 strain of herpes simplex virus 1 and used this system in rats along with conventional neuroanatomical tracing with cholera toxin B to identify subcircuits in the brainstem and forebrain that are in receipt of relayed airway sensory inputs via the Sol and Pa5. We show that both the Pa5 and proximal airways disproportionately receive afferent terminals arising from the jugular (rather than nodose) vagal ganglia and the output of the Pa5 is predominately directed toward the ventrobasal thalamus. We propose the existence of a somatosensory-like pathway from the proximal airways involving jugular ganglia afferents, the Pa5, and the somatosensory thalamus and suggest that this pathway forms the anatomical framework for sensations arising from the proximal airway mucosa.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 95 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 28%
Researcher 22 23%
Student > Master 9 9%
Other 6 6%
Student > Doctoral Student 6 6%
Other 19 20%
Unknown 7 7%
Readers by discipline Count As %
Neuroscience 38 40%
Agricultural and Biological Sciences 21 22%
Medicine and Dentistry 13 14%
Biochemistry, Genetics and Molecular Biology 4 4%
Psychology 3 3%
Other 6 6%
Unknown 11 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2019.
All research outputs
#849,571
of 24,627,841 outputs
Outputs from Journal of Neuroscience
#1,332
of 23,844 outputs
Outputs of similar age
#10,425
of 269,285 outputs
Outputs of similar age from Journal of Neuroscience
#27
of 354 outputs
Altmetric has tracked 24,627,841 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 23,844 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.6. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,285 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 354 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.