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X Demographics
Mendeley readers
Attention Score in Context
| Title |
FTD and ALS—translating mouse studies into clinical trials
|
|---|---|
| Published in |
Nature Reviews Neurology, May 2015
|
| DOI | 10.1038/nrneurol.2015.65 |
| Pubmed ID | |
| Authors |
Lars M. Ittner, Glenda M. Halliday, Jillian J. Kril, Jürgen Götz, John R. Hodges, Matthew C. Kiernan |
| Abstract |
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are related neurodegenerative disorders, which are characterized by a rapid decline in cognitive and motor functions, and short survival. Although the clinical and neuropathological characterization of these diseases has progressed-in part-through animal studies of pathogenetic mechanisms, the translation of findings from rodent models to clinical practice has generally not been successful. This article discusses the gap between preclinical animal studies in mice and clinical trials in patients with FTD or ALS. We outline how to better design preclinical studies, and present strategies to improve mouse models to overcome the translational shortfall. This new approach could help identify drugs that are more likely to achieve a therapeutic benefit for patients. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 3 | 23% |
| United States | 2 | 15% |
| United Kingdom | 2 | 15% |
| Spain | 1 | 8% |
| Brazil | 1 | 8% |
| Unknown | 4 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 77% |
| Scientists | 2 | 15% |
| Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 161 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| France | 1 | <1% |
| Australia | 1 | <1% |
| Austria | 1 | <1% |
| Unknown | 155 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 24% |
| Researcher | 23 | 14% |
| Student > Master | 23 | 14% |
| Student > Bachelor | 14 | 9% |
| Other | 12 | 7% |
| Other | 28 | 17% |
| Unknown | 22 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 23% |
| Neuroscience | 31 | 19% |
| Medicine and Dentistry | 26 | 16% |
| Biochemistry, Genetics and Molecular Biology | 13 | 8% |
| Psychology | 7 | 4% |
| Other | 18 | 11% |
| Unknown | 29 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2021.
All research outputs
#1,274,682
of 23,206,358 outputs
Outputs from Nature Reviews Neurology
#285
of 2,094 outputs
Outputs of similar age
#17,105
of 265,305 outputs
Outputs of similar age from Nature Reviews Neurology
#4
of 48 outputs
Altmetric has tracked 23,206,358 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,094 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.9. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,305 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.