| Title |
Dietary Supplementation of Walnut Partially Reverses 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Neurodegeneration in a Mouse Model of Parkinson’s Disease
|
|---|---|
| Published in |
Neurochemical Research, May 2015
|
| DOI | 10.1007/s11064-015-1593-2 |
| Pubmed ID | |
| Authors |
Musthafa Mohamed Essa, Selvaraju Subash, Chinnasamy Dhanalakshmi, Thamilarasan Manivasagam, Samir Al-Adawi, Gilles J. Guillemin, Arokiasamy Justin Thenmozhi |
| Abstract |
Numerous studies indicating that natural plant sources and their active phytochemicals offer protection to the pathological processes related to the development of neurogenerative diseases including Parkinson's disease (PD). In the present study, the neuro protective efficacy of dietary supplementation of walnut (6 %) for 28 days was examined in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (i.p., 20 mg/kg body weight/day) for last four consecutive days. MPTP injection diminished the levels of GSH, dopamine and metabolites along with decreased activities of GPx and mitochondrial complex I. Further, the levels of TBARS and enzymatic antioxidants such as SOD and catalase, MAO-B activities were enhanced by MPTP treatment. Behavioral deficits and lowered TH expression are also proved MPTP induced neurotoxicity. Dietary supplementation of walnut attenuated MPTP-induced impairment in PD mice might be by its MAO-B inhibitory, antioxidant and mitochondrial protective actions. To find out the exact mechanism of action walnut on PD mice warrants further extensive studies. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 6 | 20% |
| Student > Ph. D. Student | 6 | 20% |
| Student > Doctoral Student | 2 | 7% |
| Professor | 2 | 7% |
| Student > Bachelor | 1 | 3% |
| Other | 2 | 7% |
| Unknown | 11 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 17% |
| Neuroscience | 4 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 10% |
| Chemistry | 3 | 10% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Other | 2 | 7% |
| Unknown | 11 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2016.
All research outputs
#16,198,675
of 24,641,327 outputs
Outputs from Neurochemical Research
#1,302
of 2,222 outputs
Outputs of similar age
#153,341
of 269,309 outputs
Outputs of similar age from Neurochemical Research
#19
of 32 outputs
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