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An RNA aptamer that specifically binds pancreatic adenocarcinoma up-regulated factor inhibits migration and growth of pancreatic cancer cells

Overview of attention for article published in Cancer Letters, September 2011
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

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1 X user
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2 patents
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1 Facebook page

Citations

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60 Mendeley
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Title
An RNA aptamer that specifically binds pancreatic adenocarcinoma up-regulated factor inhibits migration and growth of pancreatic cancer cells
Published in
Cancer Letters, September 2011
DOI 10.1016/j.canlet.2011.08.027
Pubmed ID
Authors

Yun-Hee Kim, Ho Jin Sung, Sukyoung Kim, Eun-Ok Kim, Ji Won Lee, Ju Young Moon, Kyungho Choi, Ji-Eun Jung, Yangsoon Lee, Sang Seok Koh, Sue Goo Rhee, Kyun Heo, In-Hoo Kim

Abstract

Previously, we reported that a novel secretory protein, pancreatic adenocarcinoma up-regulated factor (PAUF), which is highly expressed in pancreatic cancer and mediates the growth and metastasis of pancreatic cancer cells. In this study, we generated and characterized a 2'-fluoropyrimidine modified RNA aptamer (P12FR2) directed against human PAUF. P12FR2 binds specifically to human PAUF with an estimated apparent K(D) of 77nM. P12FR2 aptamer inhibits PAUF-induced migration of PANC-1, human pancreatic cancer cells, in a wound healing assay. Moreover, intraperitoneal injection of P12FR2 decreased tumor growth by about 60% in an in vivo xenograft model with CFPAC-1 pancreatic cancer cells, without causing a loss of weight in the treated mice. Taken together, we propose here that PAUF-specific RNA aptamer, P12FR2, has the potential to be effective in the therapy of human pancreatic cancer.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 2%
Unknown 59 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 25%
Researcher 11 18%
Student > Master 8 13%
Student > Bachelor 4 7%
Other 3 5%
Other 6 10%
Unknown 13 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 20%
Biochemistry, Genetics and Molecular Biology 8 13%
Chemistry 7 12%
Engineering 6 10%
Medicine and Dentistry 4 7%
Other 9 15%
Unknown 14 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2016.
All research outputs
#4,759,600
of 25,373,627 outputs
Outputs from Cancer Letters
#750
of 6,177 outputs
Outputs of similar age
#24,873
of 136,034 outputs
Outputs of similar age from Cancer Letters
#7
of 42 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,177 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 136,034 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.