| Title |
T Cells—Protective or Pathogenic in Alzheimer’s Disease?
|
|---|---|
| Published in |
Journal of Neuroimmune Pharmacology, May 2015
|
| DOI | 10.1007/s11481-015-9612-2 |
| Pubmed ID | |
| Authors |
Róisín M. McManus, Kingston H. G. Mills, Marina A. Lynch |
| Abstract |
Alzheimer's disease (AD) is the most common cause of dementia, and is characterised by deposits of amyloid β (Aβ), neurofibrillary tangles and neuronal loss. Neuroinflammatory changes have been identified as a feature of the disease, and recent studies have suggested a potential role for the peripheral immune system in driving these changes and, ultimately, the associated neuronal degeneration. A number of reports have detailed changes in the activation state and subtype of T cells in the circulation and CSF of AD patients and there is evidence of T cell infiltration into the brain. In this review, we examine the possible impact of T cell infiltration in the progression of pathology in AD and consider the data obtained from animal models of the disease. We consider how these cells infiltrate the brain, particularly in AD, and discuss whether the presence of T cells in the AD brain is protective or pathogenic. Finally we evaluate the current therapies, particularly those that involve immunization. |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 63 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 22% |
| Student > Master | 9 | 14% |
| Researcher | 8 | 13% |
| Student > Doctoral Student | 6 | 9% |
| Professor | 5 | 8% |
| Other | 11 | 17% |
| Unknown | 11 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 15 | 23% |
| Medicine and Dentistry | 10 | 16% |
| Immunology and Microbiology | 7 | 11% |
| Biochemistry, Genetics and Molecular Biology | 6 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
| Other | 6 | 9% |
| Unknown | 15 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2015.
All research outputs
#4,544,447
of 24,217,893 outputs
Outputs from Journal of Neuroimmune Pharmacology
#128
of 583 outputs
Outputs of similar age
#54,453
of 267,948 outputs
Outputs of similar age from Journal of Neuroimmune Pharmacology
#8
of 18 outputs
Altmetric has tracked 24,217,893 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 583 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,948 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.