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Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis

Overview of attention for article published in Cancer Causes & Control, May 2015
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Title
Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis
Published in
Cancer Causes & Control, May 2015
DOI 10.1007/s10552-015-0595-3
Pubmed ID
Authors

Annaka Schulte, Nirmala Pandeya, Jonathan Fawcett, Lin Fritschi, Harvey A. Risch, Penelope M. Webb, David C. Whiteman, Rachel E. Neale

Abstract

Gastric colonization with Helicobacter pylori (H. pylori) has been implicated in the pathogenesis of pancreatic cancer, but results of epidemiological studies have been inconclusive. We analyzed data from the Queensland Pancreatic Cancer Study, an Australian population-based case-control study, and incorporated our findings into an updated meta-analysis. Blood samples were obtained from 580 patients and 626 controls, and enzyme-linked immunosorbent assay kits were used to determine seropositivity to H. pylori and its virulence protein, cytotoxin-associated gene A (CagA). Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using logistic regression. Results were incorporated into a meta-analysis along with results of studies identified through systematic literature review. Adjusted ORs and 95 % CIs were calculated using the DerSimonian and Laird random-effects model. No overall association was observed between H. pylori seropositivity and risk of pancreatic cancer (OR 1.00; 95 % CI 0.74-1.35). Nonsignificantly decreased pancreatic cancer risk was observed with CagA seropositivity (OR 0.74; 95 % CI 0.48-1.15) and increased risk with CagA-negative H. pylori seropositivity (OR 1.23; 95 % CI 0.83-1.82). Ten studies were included in the meta-analysis. There was no significant overall association between H. pylori seropositivity and pancreatic cancer risk (OR 1.13; 95 % CI 0.86-1.50), but evidence of CagA strain-specific associations (OR 0.78; 95 % CI 0.67-0.91 and OR 1.30; 95 % CI 1.02-1.65 for CagA-positive and CagA-negative strains, respectively). Our results provide further evidence for the existence of strain-specific associations between H. pylori and pancreatic cancer.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Greece 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 26%
Student > Bachelor 8 14%
Student > Master 6 11%
Student > Ph. D. Student 6 11%
Student > Postgraduate 3 5%
Other 7 12%
Unknown 12 21%
Readers by discipline Count As %
Medicine and Dentistry 23 40%
Biochemistry, Genetics and Molecular Biology 10 18%
Agricultural and Biological Sciences 5 9%
Immunology and Microbiology 4 7%
Psychology 1 2%
Other 1 2%
Unknown 13 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2015.
All research outputs
#17,419,110
of 25,559,053 outputs
Outputs from Cancer Causes & Control
#1,701
of 2,269 outputs
Outputs of similar age
#169,511
of 279,551 outputs
Outputs of similar age from Cancer Causes & Control
#20
of 28 outputs
Altmetric has tracked 25,559,053 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,269 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,551 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.