| Title |
The receptor CD44 is associated with systemic insulin resistance and proinflammatory macrophages in human adipose tissue
|
|---|---|
| Published in |
Diabetologia, May 2015
|
| DOI | 10.1007/s00125-015-3603-y |
| Pubmed ID | |
| Authors |
Li Fen Liu, Keiichi Kodama, Ke Wei, Lorna L. Tolentino, Okmi Choi, Edgar G. Engleman, Atul J. Butte, Tracey McLaughlin |
| Abstract |
Proinflammatory immune cell infiltration in human adipose tissue is associated with the development of insulin resistance. We previously identified, via a gene expression-based genome-wide association study, the cell-surface immune cell receptor CD44 as a functionally important gene associated with type 2 diabetes. We then showed that, compared with controls, Cd44 knockout mice were protected from insulin resistance and adipose tissue inflammation during diet-induced obesity. We thus sought to test whether CD44 is associated with adipose tissue inflammation and insulin resistance in humans. Participants included 58 healthy, overweight/moderately obese white adults who met predetermined criteria for insulin resistance or insulin sensitivity based on the modified insulin-suppression test. Serum was collected from 43 participants to measure circulating concentrations of CD44. Subcutaneous adipose tissue was obtained from 17 participants to compare CD44, its ligand osteopontin (OPN, also known as SPP1) and pro-inflammatory gene expression. CD44 expression on adipose tissue macrophage (ATM) surfaces was determined by flow cytometry. Serum CD44 concentrations were significantly increased in insulin-resistant (IR) participants. CD44 gene expression in subcutaneous adipose tissue was threefold higher in the IR subgroup. The expression of OPN, CD68 and IL6 was also significantly elevated in IR individuals. CD44 gene expression correlated significantly with CD68 and IL6 expression. CD44 density on ATMs was associated with proinflammatory M1 polarisation. CD44 and OPN in human adipose tissue are associated with localised inflammation and systemic insulin resistance. This receptor-ligand pair is worthy of further research as a potentially modifiable contributor to human insulin resistance and type 2 diabetes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | 1% |
| Unknown | 79 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 16% |
| Student > Ph. D. Student | 11 | 14% |
| Student > Doctoral Student | 9 | 11% |
| Student > Bachelor | 9 | 11% |
| Researcher | 7 | 9% |
| Other | 14 | 18% |
| Unknown | 17 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 19 | 24% |
| Medicine and Dentistry | 14 | 18% |
| Agricultural and Biological Sciences | 9 | 11% |
| Immunology and Microbiology | 7 | 9% |
| Nursing and Health Professions | 3 | 4% |
| Other | 6 | 8% |
| Unknown | 22 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2015.
All research outputs
#18,409,030
of 22,803,211 outputs
Outputs from Diabetologia
#4,676
of 5,035 outputs
Outputs of similar age
#191,927
of 263,982 outputs
Outputs of similar age from Diabetologia
#68
of 76 outputs
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