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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Versatile Approach for the Site‐Specific Modification of Recombinant Antibodies Using a Combination of Enzyme‐Mediated Bioconjugation and Click Chemistry
|
|---|---|
| Published in |
Angewandte Chemie. International Edition, May 2015
|
| DOI | 10.1002/anie.201411507 |
| Pubmed ID | |
| Authors |
Karen Alt, Brett M. Paterson, Erik Westein, Stacey E. Rudd, Stan S. Poniger, Shweta Jagdale, Katie Ardipradja, Timothy U. Connell, Guy Y. Krippner, Ashish K. N. Nair, Xiaowei Wang, Henri J. Tochon‐Danguy, Paul S. Donnelly, Karlheinz Peter, Christoph E. Hagemeyer |
| Abstract |
A unique two-step modular system for site-specific antibody modification and conjugation is reported. The first step of this approach uses enzymatic bioconjugation with the transpeptidase Sortase A for incorporation of strained cyclooctyne functional groups. The second step of this modular approach involves the azide-alkyne cycloaddition click reaction. The versatility of the two-step approach has been exemplified by the selective incorporation of fluorescent dyes and a positron-emitting copper-64 radiotracer for fluorescence and positron-emission tomography imaging of activated platelets, platelet aggregates, and thrombi, respectively. This flexible and versatile approach could be readily adapted to incorporate a large array of tailor-made functional groups using reliable click chemistry whilst preserving the activity of the antibody or other sensitive biological macromolecules. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 33% |
| Australia | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 67% |
| Members of the public | 1 | 17% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Netherlands | 1 | 1% |
| China | 1 | 1% |
| Japan | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 78 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 30% |
| Researcher | 20 | 24% |
| Student > Master | 7 | 8% |
| Student > Bachelor | 6 | 7% |
| Student > Postgraduate | 6 | 7% |
| Other | 10 | 12% |
| Unknown | 10 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 40 | 48% |
| Agricultural and Biological Sciences | 12 | 14% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Medicine and Dentistry | 3 | 4% |
| Engineering | 3 | 4% |
| Other | 5 | 6% |
| Unknown | 14 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2024.
All research outputs
#3,653,903
of 25,738,558 outputs
Outputs from Angewandte Chemie. International Edition
#11,350
of 50,682 outputs
Outputs of similar age
#44,495
of 279,803 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#216
of 696 outputs
Altmetric has tracked 25,738,558 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 50,682 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,803 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 696 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.