| Title |
Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects
|
|---|---|
| Published in |
Internal and Emergency Medicine, March 2011
|
| DOI | 10.1007/s11739-011-0559-x |
| Pubmed ID | |
| Authors |
Alfonso Bellia, Caterina Garcovich, Monica D’Adamo, Mauro Lombardo, Manfredi Tesauro, Giulia Donadel, Paolo Gentileschi, Davide Lauro, Massimo Federici, Renato Lauro, Paolo Sbraccia |
| Abstract |
Obesity is frequently characterized by a reduced vitamin D bioavailability, as well as insulin-resistance and a chronic inflammatory response. We tested the hypothesis of an independent relationship between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and several circulating inflammatory markers in a cohort of severely obese individuals. Cross-sectional study was carried out among obese patients undergoing a clinical evaluation before bariatric surgery in our University Hospital. Serum 25(OH)D, fasting and post load glucose and insulin, high-sensitive C-reactive protein (hs CRP), fibrinogen, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), leptin, adiponectin and lipid profile were collected. Insulin-resistance was assessed by insulin sensitivity index (ISI). Total body fat (FAT kg), total percent body fat (FAT%) and truncal fat mass (TrFAT) were assessed with dual-energy X-ray absorptiometry. A total of 147 obese subjects (89 women, 37.8 ± 7.1 years) with mean body mass index (BMI) of 43.6 ± 4.3 kg/m(2) were enrolled. Patients in the lowest tertile of 25(OH)D were significantly more obese with a higher amount of TrFAT, more insulin-resistant, and had higher levels of fasting and post-challenge glucose (p < 0.05 for all). In a multivariate regression analysis, serum 25(OH)D was inversely related to significant levels of hs CRP, IL-6 and TNF-α after accounting for age, gender, season of recruitment, BMI, FAT kg and TrFAT (p < 0.01 for all). In extremely obese subjects, 25(OH)D serum concentrations are inversely associated with several biomarkers of systemic inflammation, regardless of the total quantity of fat mass. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Portugal | 1 | <1% |
| Unknown | 107 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 17% |
| Student > Master | 15 | 14% |
| Student > Bachelor | 15 | 14% |
| Student > Ph. D. Student | 11 | 10% |
| Other | 7 | 6% |
| Other | 20 | 18% |
| Unknown | 23 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 42 | 39% |
| Agricultural and Biological Sciences | 9 | 8% |
| Biochemistry, Genetics and Molecular Biology | 7 | 6% |
| Nursing and Health Professions | 6 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Other | 13 | 12% |
| Unknown | 27 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2021.
All research outputs
#17,756,606
of 22,803,211 outputs
Outputs from Internal and Emergency Medicine
#664
of 939 outputs
Outputs of similar age
#94,358
of 108,629 outputs
Outputs of similar age from Internal and Emergency Medicine
#6
of 6 outputs
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