| Title |
Comparison of epidemiology and clinical characteristics of infections by human parechovirus vs. those by enterovirus during the first month of life
|
|---|---|
| Published in |
European Journal of Pediatrics, May 2015
|
| DOI | 10.1007/s00431-015-2566-9 |
| Pubmed ID | |
| Authors |
María Cabrerizo, Gloria Trallero, María José Pena, Amaia Cilla, Gregoria Megias, Carmen Muñoz-Almagro, Eva Del Amo, Diana Roda, Ana Isabel Mensalvas, Antonio Moreno-Docón, Juan García-Costa, Nuria Rabella, Manuel Omeñaca, María Pilar Romero, Sara Sanbonmatsu-Gámez, Mercedes Pérez-Ruiz, María José Santos-Muñoz, Cristina Calvo |
| Abstract |
Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patients compared with those infected by enterovirus (EV). Infants <1 month with neurological or systemic symptoms were included in a multicentre prospective study. EV and HPeV detection by RT-PCR and genotyping were performed in cerebrospinal fluids (CSF), sera or throat swabs. Out of the total of 84 infants studied during 2013, 32 were EV positive (38 %) and 9 HPeV positive (11 %). HPeV-3 was identified in eight cases and HPeV-5 in one. Mean age of HPeV-positive patients was 18 days. Diagnoses were fever without source (FWS) (67 %), clinical sepsis (22 %) and encephalitis (11 %). Leukocytes in blood and CSF were normal. Pleocytosis (p = 0.03) and meningitis (p = 0.001) were significantly more frequent in patients with EV infections than with HPeV. Although HPeV-3 infections were detected less frequently than EV, they still account for approximately 10 % of the cases analysed in infants younger than 1 month. HPeV-3 was mainly associated with FWS and without leukocytosis and pleocytosis in CSF. In these cases, HPeV screening is desirable to identify the aetiologic agent and prevent unnecessary treatment and prolonged hospitalization. What is Known: • Human parechovirus may be a cause of fever and clinical sepsis in the neonatal period. • HPeV-3 might be one of the main agents causing severe neonatal neurological infections. What is New: • This is the first multicenter prospective study focused on newborns and contributes to a better knowledge of these viral infections. Clinical characteristics of enterovirus and parechovirus infections are compared specifically in the neonatal period. • Knowledge of HPeV infections by paediatricians and neonatologists can guide the diagnosis of these patients and avoid unnecessary treatment and prolonged hospitalization. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 50% |
| United Kingdom | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Netherlands | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 78 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 19% |
| Other | 11 | 14% |
| Researcher | 11 | 14% |
| Student > Bachelor | 10 | 12% |
| Student > Master | 6 | 7% |
| Other | 18 | 22% |
| Unknown | 10 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 53% |
| Agricultural and Biological Sciences | 6 | 7% |
| Immunology and Microbiology | 6 | 7% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Nursing and Health Professions | 2 | 2% |
| Other | 3 | 4% |
| Unknown | 18 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2015.
All research outputs
#15,331,767
of 22,803,211 outputs
Outputs from European Journal of Pediatrics
#2,783
of 3,697 outputs
Outputs of similar age
#156,680
of 265,295 outputs
Outputs of similar age from European Journal of Pediatrics
#27
of 56 outputs
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