Title |
The Forgotten Role of Glucose Effectiveness in the Regulation of Glucose Tolerance
|
---|---|
Published in |
Current Diabetes Reports, April 2015
|
DOI | 10.1007/s11892-015-0605-6 |
Pubmed ID | |
Authors |
Simmi Dube, Isabel Errazuriz-Cruzat, Ananda Basu, Rita Basu |
Abstract |
Glucose effectiveness (S G) is the ability of glucose per se to stimulate its own uptake and to suppress its own production under basal/constant insulin concentrations. In an individual, glucose tolerance is a function of insulin secretion, insulin action and S G. Under conditions of declining insulin secretion and action (e.g. type 2 diabetes), the degree of S G assumes increasing significance in determining the level of glucose tolerance both in fasted and postprandial states. Although the importance of S G has been recognized for years, mechanisms that contribute to S G are poorly understood. Research data on modulation of S G and its impact in glucose intolerance is limited. In this review, we will focus on the role of S G in the regulation of glucose tolerance, its evaluation, and potential advantages of therapies that can enhance glucose-induced stimulation of glucose uptake and suppression of its own production in conditions of impaired insulin secretion and action. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 24% |
Researcher | 8 | 16% |
Student > Master | 7 | 14% |
Student > Bachelor | 6 | 12% |
Student > Doctoral Student | 3 | 6% |
Other | 12 | 24% |
Unknown | 2 | 4% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 30% |
Biochemistry, Genetics and Molecular Biology | 7 | 14% |
Nursing and Health Professions | 4 | 8% |
Agricultural and Biological Sciences | 4 | 8% |
Engineering | 3 | 6% |
Other | 9 | 18% |
Unknown | 8 | 16% |