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Dynamics of brain iron levels in multiple sclerosis

Overview of attention for article published in Neurology, May 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

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1 blog
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17 X users
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2 Facebook pages
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1 Google+ user

Citations

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61 Dimensions

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69 Mendeley
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Title
Dynamics of brain iron levels in multiple sclerosis
Published in
Neurology, May 2015
DOI 10.1212/wnl.0000000000001679
Pubmed ID
Authors

Michael Khalil, Christian Langkammer, Alexander Pichler, Daniela Pinter, Thomas Gattringer, Gerhard Bachmaier, Stefan Ropele, Siegrid Fuchs, Christian Enzinger, Franz Fazekas

Abstract

We investigated longitudinal changes in iron concentration in the subcortical gray matter (caudate nucleus, globus pallidus, putamen, thalamus) of patients with clinically isolated syndrome (CIS) and definite multiple sclerosis (MS) and their relation to clinical and other morphologic variables. We followed 144 patients (76 CIS; median Expanded Disability Status Scale [EDSS] 1.0 [interquartile range (IQR) 0.0-2.0]; 68 MS; median EDSS 2.0 [IQR 1.0-3.3]) clinically and with 3T MRI over a median period of 2.9 (IQR 1.3-4.0) years. Iron concentration was determined by R2* relaxometry at baseline and last follow-up. At baseline, subcortical gray matter iron deposition was higher in MS compared to CIS. In CIS, R2* rates increased in the globus pallidus (p < 0.001), putamen (p < 0.001), and caudate nucleus (p < 0.001), whereas R2* rates in the thalamus decreased (p < 0.05). In MS, R2* rates increased in the putamen (p < 0.05), remained stable in the globus pallidus and caudate nucleus, and decreased in the thalamus (p < 0.01). Changes in R2* relaxation rates were unrelated to changes in the volume of respective structures, of T2 lesion load, and of disability. Iron accumulation in the basal ganglia is more pronounced in the early than later phases of the disease and occurs independent from other morphologic brain changes. Short-term changes in iron concentration are not associated with disease activity or changes in disability.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Austria 2 3%
United States 1 1%
Unknown 66 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 20%
Student > Ph. D. Student 12 17%
Professor 6 9%
Professor > Associate Professor 6 9%
Student > Master 6 9%
Other 17 25%
Unknown 8 12%
Readers by discipline Count As %
Medicine and Dentistry 30 43%
Neuroscience 12 17%
Physics and Astronomy 4 6%
Psychology 3 4%
Biochemistry, Genetics and Molecular Biology 3 4%
Other 8 12%
Unknown 9 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2015.
All research outputs
#1,924,081
of 25,377,790 outputs
Outputs from Neurology
#3,647
of 21,010 outputs
Outputs of similar age
#24,031
of 279,381 outputs
Outputs of similar age from Neurology
#45
of 223 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 21,010 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.7. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,381 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 223 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.