| Title |
Systemic oxidative stress could predict assisted reproductive technique outcome
|
|---|---|
| Published in |
Journal of Assisted Reproduction and Genetics, March 2015
|
| DOI | 10.1007/s10815-015-0466-6 |
| Pubmed ID | |
| Authors |
A. Ahelik, R. Mändar, P. Korrovits, P. Karits, E. Talving, K. Rosenstein, M. Jaagura, A. Salumets, T. Kullisaar |
| Abstract |
Previous studies have indicated that OxS (oxidative stress) may appear as a possible reason for poor ART outcome. Our aim was to study OxS levels in both partners of couples seeking Assisted reproduction Technology (ART). Altogether 79 couples were recruited. Oxidative DNA damage (8-OHdG) and lipid peroxidation (8-EPI) were measured, and clinical background and ART outcomes were recorded. Both OxS markers accurately reflected clincal conditions with prominent negative effects attributable to genital tract infections, endometriosis, uterine myoma and smoking. Furthermore, the level of OxS was also affected by partner's state of health. The highest 8-EPI levels were detected in both partners when biochemically detectable pregnancies did not develop into clinically detectable pregnancies (in women, 97,8 ± 16,7 vs 72.9 ± 22,9, p = 0.007; in men, 89.6 ± 20,4 vs 72,1 ± 22,6, p = 0.049). To conclude, high grade systemix OxS in both partners may negatively affect the maintenance and outcome of pregnancy. Applying the detection of OxS in ART patients may select patients with higher success rate and/or those who require antioxidant therapy. This would lead to improvement of ART outcome as well as natural fertility. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Cayman Islands | 1 | 50% |
| Spain | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Russia | 1 | 1% |
| Unknown | 75 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 21% |
| Student > Master | 15 | 19% |
| Other | 7 | 9% |
| Researcher | 7 | 9% |
| Student > Bachelor | 7 | 9% |
| Other | 13 | 17% |
| Unknown | 12 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 35% |
| Biochemistry, Genetics and Molecular Biology | 9 | 12% |
| Agricultural and Biological Sciences | 7 | 9% |
| Nursing and Health Professions | 6 | 8% |
| Psychology | 5 | 6% |
| Other | 9 | 12% |
| Unknown | 14 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2016.
All research outputs
#16,371,088
of 24,119,703 outputs
Outputs from Journal of Assisted Reproduction and Genetics
#963
of 1,697 outputs
Outputs of similar age
#161,626
of 267,867 outputs
Outputs of similar age from Journal of Assisted Reproduction and Genetics
#14
of 28 outputs
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So far Altmetric has tracked 1,697 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
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