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Genome sequencing reveals insights into physiology and longevity of the naked mole rat

Overview of attention for article published in Nature, October 2011
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Citations

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512 Dimensions

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1050 Mendeley
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5 CiteULike
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Title
Genome sequencing reveals insights into physiology and longevity of the naked mole rat
Published in
Nature, October 2011
DOI 10.1038/nature10533
Pubmed ID
Authors

Eun Bae Kim, Xiaodong Fang, Alexey A. Fushan, Zhiyong Huang, Alexei V. Lobanov, Lijuan Han, Stefano M. Marino, Xiaoqing Sun, Anton A. Turanov, Pengcheng Yang, Sun Hee Yim, Xiang Zhao, Marina V. Kasaikina, Nina Stoletzki, Chunfang Peng, Paz Polak, Zhiqiang Xiong, Adam Kiezun, Yabing Zhu, Yuanxin Chen, Gregory V. Kryukov, Qiang Zhang, Leonid Peshkin, Lan Yang, Roderick T. Bronson, Rochelle Buffenstein, Bo Wang, Changlei Han, Qiye Li, Li Chen, Wei Zhao, Shamil R. Sunyaev, Thomas J. Park, Guojie Zhang, Jun Wang, Vadim N. Gladyshev

Abstract

The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis. Although characterized by significant oxidative stress, the naked mole rat proteome does not show age-related susceptibility to oxidative damage or increased ubiquitination. Naked mole rats naturally reside in large colonies with a single breeding female, the 'queen', who suppresses the sexual maturity of her subordinates. They also live in full darkness, at low oxygen and high carbon dioxide concentrations, and are unable to sustain thermogenesis nor feel certain types of pain. Here we report the sequencing and analysis of the naked mole rat genome, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing. This information provides insights into the naked mole rat's exceptional longevity and ability to live in hostile conditions, in the dark and at low oxygen. The extreme traits of the naked mole rat, together with the reported genome and transcriptome information, offer opportunities for understanding ageing and advancing other areas of biological and biomedical research.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,050 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 23 2%
United Kingdom 9 <1%
Japan 8 <1%
Germany 5 <1%
China 5 <1%
Sweden 3 <1%
Spain 3 <1%
Belgium 3 <1%
Brazil 3 <1%
Other 19 2%
Unknown 969 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 252 24%
Student > Ph. D. Student 242 23%
Student > Bachelor 109 10%
Student > Master 101 10%
Professor > Associate Professor 62 6%
Other 152 14%
Unknown 132 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 540 51%
Biochemistry, Genetics and Molecular Biology 187 18%
Medicine and Dentistry 44 4%
Neuroscience 20 2%
Physics and Astronomy 14 1%
Other 86 8%
Unknown 159 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 317. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2023.
All research outputs
#107,705
of 25,576,275 outputs
Outputs from Nature
#7,354
of 98,255 outputs
Outputs of similar age
#348
of 148,734 outputs
Outputs of similar age from Nature
#23
of 938 outputs
Altmetric has tracked 25,576,275 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,255 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.6. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 148,734 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 938 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.