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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Modulation of motivational salience processing during the early stages of psychosis
|
|---|---|
| Published in |
Schizophrenia Research, May 2015
|
| DOI | 10.1016/j.schres.2015.04.036 |
| Pubmed ID | |
| Authors |
Renata Smieskova, Jonathan P Roiser, Christopher A Chaddock, André Schmidt, Fabienne Harrisberger, Kerstin Bendfeldt, Andor Simon, Anna Walter, Paolo Fusar-Poli, Philip K McGuire, Undine E Lang, Anita Riecher-Rössler, Stefan Borgwardt |
| Abstract |
Deficits in motivational salience processing have been related to psychotic symptoms and disturbances in dopaminergic neurotransmission. We aimed at exploring changes in salience processing and brain activity during different stages of psychosis and antipsychotic medication effect. We used fMRI during the Salience Attribution Task to investigate hemodynamic differences between 19 healthy controls (HCs), 34 at-risk mental state (ARMS) individuals and 29 individuals with first-episode psychosis (FEP), including a subgroup of 17 FEP without antipsychotic medication (FEP-UM) and 12 FEP with antipsychotic medication (FEP-M). Motivational salience processing was operationalized by brain activity in response to high-probability rewarding cues (adaptive salience) and in response to low-probability rewarding cues (aberrant salience). Behaviorally, adaptive salience response was not accelerated in FEP, although they correctly distinguished between trials with low and high reward probability. In comparison to HC, ARMS exhibited a lower hemodynamic response during adaptive salience in the right inferior parietal lobule and FEP-UM in the left dorsal cingulate gyrus. The FEP-M group exhibited a lower adaptive salience response than HC in the right insula and than ARMS in the anterior cingulate gyrus. In unmedicated individuals, the severity of hallucinations and delusions correlated negatively with the insular- and anterior cingulate hemodynamic response during adaptive salience. We found no differences in aberrant salience processing associated with behavior or medication. The changes in adaptive motivational salience processing during psychosis development reveal neurofunctional abnormalities in the somatosensory and premotor cortex. Antipsychotic medication seems to modify hemodynamic responses in the anterior cingulate and insula. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| United Kingdom | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 139 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 17% |
| Researcher | 23 | 16% |
| Student > Master | 18 | 13% |
| Professor | 9 | 6% |
| Student > Bachelor | 8 | 6% |
| Other | 24 | 17% |
| Unknown | 36 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 34 | 24% |
| Neuroscience | 30 | 21% |
| Medicine and Dentistry | 22 | 15% |
| Business, Management and Accounting | 2 | 1% |
| Arts and Humanities | 2 | 1% |
| Other | 6 | 4% |
| Unknown | 47 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2015.
All research outputs
#16,045,990
of 25,371,288 outputs
Outputs from Schizophrenia Research
#3,275
of 5,684 outputs
Outputs of similar age
#148,958
of 279,392 outputs
Outputs of similar age from Schizophrenia Research
#47
of 120 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,684 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,392 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 120 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.