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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth
|
|---|---|
| Published in |
Nature Immunology, May 2015
|
| DOI | 10.1038/ni.3170 |
| Pubmed ID | |
| Authors |
Claudia Bossen, Caroline S Murre, Aaron N Chang, Robert Mansson, Hans-Reimer Rodewald, Cornelis Murre |
| Abstract |
Early B cell development is orchestrated by the combined activities of the transcriptional regulators E2A, EBF1, Foxo1 and Ikaros. However, how the genome-wide binding patterns of these regulators are modulated during B lineage development remains to be determined. Here we found that in lymphoid progenitor cells, the chromatin remodeler Brg1 specified the B cell fate. In committed pro-B cells, Brg1 regulated contraction of the locus encoding the immunoglobulin heavy chain (Igh) and controlled expression of the gene encoding the transcription factor c-Myc (Myc) to modulate the expression of genes encoding products that regulate ribosome biogenesis. In committed pro-B cells, Brg1 suppressed a pre-B lineage-specific pattern of gene expression. Finally, we found that Brg1 acted mechanistically to establish B cell fate and modulate cell growth by facilitating access of lineage-specific transcription factors to enhancer repertoires. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 33% |
| France | 1 | 11% |
| Switzerland | 1 | 11% |
| Turkey | 1 | 11% |
| Unknown | 3 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 56% |
| Scientists | 4 | 44% |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Austria | 1 | <1% |
| United Kingdom | 1 | <1% |
| China | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 142 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 44 | 30% |
| Researcher | 28 | 19% |
| Student > Master | 12 | 8% |
| Student > Doctoral Student | 11 | 7% |
| Student > Bachelor | 11 | 7% |
| Other | 18 | 12% |
| Unknown | 24 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 53 | 36% |
| Biochemistry, Genetics and Molecular Biology | 42 | 28% |
| Medicine and Dentistry | 9 | 6% |
| Immunology and Microbiology | 8 | 5% |
| Computer Science | 3 | 2% |
| Other | 7 | 5% |
| Unknown | 26 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2023.
All research outputs
#1,891,148
of 25,284,710 outputs
Outputs from Nature Immunology
#1,116
of 4,162 outputs
Outputs of similar age
#23,351
of 271,980 outputs
Outputs of similar age from Nature Immunology
#18
of 54 outputs
Altmetric has tracked 25,284,710 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,162 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.2. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,980 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.