| Title |
Mechanism Underlying the Effects of Estrogen Deficiency on Otoconia
|
|---|---|
| Published in |
Journal of the Association for Research in Otolaryngology, April 2018
|
| DOI | 10.1007/s10162-018-0666-8 |
| Pubmed ID | |
| Authors |
Liping Yang, Yinfang Xu, Yan Zhang, Sarath Vijayakumar, Sherri M. Jones, Yunxia (Yesha) Wang Lundberg |
| Abstract |
Otoconia-related vertigo and balance deficits, particularly benign paroxysmal positional vertigo (BPPV), are common. Our recent studies in humans show that, while BPPV prevalence greatly increases with age in both genders, peri-menopausal women are especially susceptible. In the present study, we show that bilateral ovariectomized (OVX) mice have significant balance behavioral deficits, and that estrogen deficiency compromises otoconia maintenance and anchoring by reducing the expression of otoconial component and anchoring proteins. There is ectopic debris formation in the ampulla under estrogen deficiency due to aberrant matrix protein expression. Furthermore, phytoestrogen is effective in rescuing the otoconia abnormalities. By comparing the expression levels of known estrogen receptor (Esr) subtypes, and by examining the otoconia phenotypes of null mice for selected receptors, we postulate that Esr2 may be critical in mediating the effects of estrogen in otoconia maintenance. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 24% |
| Student > Master | 7 | 17% |
| Student > Bachelor | 3 | 7% |
| Unspecified | 3 | 7% |
| Student > Doctoral Student | 2 | 5% |
| Other | 6 | 14% |
| Unknown | 11 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 24% |
| Nursing and Health Professions | 5 | 12% |
| Neuroscience | 5 | 12% |
| Unspecified | 3 | 7% |
| Sports and Recreations | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 15 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2018.
All research outputs
#15,394,268
of 23,849,058 outputs
Outputs from Journal of the Association for Research in Otolaryngology
#257
of 429 outputs
Outputs of similar age
#197,560
of 328,599 outputs
Outputs of similar age from Journal of the Association for Research in Otolaryngology
#2
of 9 outputs
Altmetric has tracked 23,849,058 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 429 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
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We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.