Title |
Host–pathogen interaction during bacterial vaccination
|
---|---|
Published in |
Current Opinion in Immunology, May 2015
|
DOI | 10.1016/j.coi.2015.04.002 |
Pubmed ID | |
Authors |
Timothy C Barnett, Jin Yan Lim, Amelia T Soderholm, Tania Rivera-Hernandez, Nicholas P West, Mark J Walker |
Abstract |
Vaccines have been developed and deployed against several important bacterial pathogens of humans, including Neisseria meningitidis, Bordetella pertussis, Streptococcus pneumoniae and Mycobacterium tuberculosis. These vaccines are generally considered a successful public health measure and are effective at controlling disease symptoms and/or burden. However, a troubling consequence of recent vaccination programs has been the selection of vaccine escape mutants, whereby the pathogen displays a different repertoire of immune targets than those represented in the vaccine formulation. To address these issues of antigenic variation and bacterial evolution, continued and sustained efforts in epidemiological surveillance, vaccine development/formulation research, and understanding of the host-pathogen interaction are required. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 1% |
Netherlands | 1 | 1% |
India | 1 | 1% |
United States | 1 | 1% |
Unknown | 78 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 16 | 20% |
Student > Ph. D. Student | 13 | 16% |
Student > Bachelor | 13 | 16% |
Student > Master | 9 | 11% |
Other | 8 | 10% |
Other | 11 | 13% |
Unknown | 12 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 28 | 34% |
Medicine and Dentistry | 13 | 16% |
Immunology and Microbiology | 12 | 15% |
Biochemistry, Genetics and Molecular Biology | 10 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
Other | 5 | 6% |
Unknown | 13 | 16% |