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Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1

Overview of attention for article published in Translational Psychiatry, May 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

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6 news outlets
blogs
2 blogs
twitter
14 X users
facebook
5 Facebook pages

Citations

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34 Dimensions

Readers on

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88 Mendeley
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Title
Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1
Published in
Translational Psychiatry, May 2015
DOI 10.1038/tp.2015.60
Pubmed ID
Authors

N Dawson, M Kurihara, D M Thomson, C L Winchester, A McVie, J R Hedde, A D Randall, S Shen, P A Seymour, Z A Hughes, J Dunlop, J T Brown, N J Brandon, B J Morris, J A Pratt

Abstract

Considerable evidence implicates DISC1 as a susceptibility gene for multiple psychiatric diseases. DISC1 has been intensively studied at the molecular, cellular and behavioral level, but its role in regulating brain connectivity and brain network function remains unknown. Here, we utilize a set of complementary approaches to assess the functional brain network abnormalities present in mice expressing a truncated Disc1 gene (Disc1tr Hemi mice). Disc1tr Hemi mice exhibited hypometabolism in the prefrontal cortex (PFC) and reticular thalamus along with a reorganization of functional brain network connectivity that included compromised hippocampal-PFC connectivity. Altered hippocampal-PFC connectivity in Disc1tr Hemi mice was confirmed by electrophysiological analysis, with Disc1tr Hemi mice showing a reduced probability of presynaptic neurotransmitter release in the monosynaptic glutamatergic hippocampal CA1-PFC projection. Glutamate system dysfunction in Disc1tr Hemi mice was further supported by the attenuated cerebral metabolic response to the NMDA receptor (NMDAR) antagonist ketamine and decreased hippocampal expression of NMDAR subunits 2A and 2B in these animals. These data show that the Disc1 truncation in Disc1tr Hemi mice induces a range of translationally relevant endophenotypes underpinned by glutamate system dysfunction and altered brain connectivity.

X Demographics

X Demographics

The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
United States 1 1%
Italy 1 1%
Unknown 85 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 15%
Student > Master 12 14%
Researcher 10 11%
Professor > Associate Professor 8 9%
Student > Bachelor 7 8%
Other 15 17%
Unknown 23 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 24%
Neuroscience 18 20%
Medicine and Dentistry 7 8%
Biochemistry, Genetics and Molecular Biology 6 7%
Psychology 3 3%
Other 6 7%
Unknown 27 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 65. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2016.
All research outputs
#661,168
of 25,482,409 outputs
Outputs from Translational Psychiatry
#305
of 3,691 outputs
Outputs of similar age
#7,546
of 280,225 outputs
Outputs of similar age from Translational Psychiatry
#4
of 52 outputs
Altmetric has tracked 25,482,409 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,691 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.3. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,225 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.