Title |
Hepcidin: regulation of the master iron regulator
|
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Published in |
Bioscience Reports, May 2015
|
DOI | 10.1042/bsr20150014 |
Pubmed ID | |
Authors |
Gautam Rishi, Daniel F. Wallace, V. Nathan Subramaniam |
Abstract |
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a defined pathway to excrete excess iron makes it essential for the body to regulate the amount of iron absorbed; a deficiency could lead to iron deficiency and an excess to iron overload, and associated disorders such as anemia and hemochromatosis, respectively. This regulation is mediated by the iron-regulatory hormone hepcidin. Hepcidin binds to the only known iron export protein, ferroportin, inducing its internalization and degradation, thus limiting the amount of iron released into the blood. The major factors that are implicated in hepcidin regulation include iron stores, hypoxia, inflammation and erythropoiesis. This review summarizes our present knowledge about the molecular mechanisms and signaling pathways contributing to hepcidin regulation by these factors. |
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Canada | 1 | 13% |
United States | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
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Scientists | 1 | 13% |
Mendeley readers
Geographical breakdown
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Germany | 1 | <1% |
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Readers by professional status | Count | As % |
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Student > Bachelor | 36 | 15% |
Student > Master | 28 | 11% |
Researcher | 25 | 10% |
Student > Doctoral Student | 17 | 7% |
Other | 42 | 17% |
Unknown | 62 | 25% |
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Nursing and Health Professions | 8 | 3% |
Other | 28 | 11% |
Unknown | 75 | 30% |