| Title |
Mass cytometry as a platform for the discovery of cellular biomarkers to guide effective rheumatic disease therapy
|
|---|---|
| Published in |
Arthritis Research & Therapy, May 2015
|
| DOI | 10.1186/s13075-015-0644-z |
| Pubmed ID | |
| Authors |
Nitya Nair, Henrik E Mei, Shih-Yu Chen, Matthew Hale, Garry P Nolan, Holden T Maecker, Mark Genovese, C Garrison Fathman, Chan C Whiting |
| Abstract |
The development of biomarkers for autoimmune diseases has been hampered by a lack of understanding of disease etiopathogenesis and of the mechanisms underlying the induction and maintenance of inflammation, which involves complex activation dynamics of diverse cell types. The heterogeneous nature and suboptimal clinical response to treatment observed in many autoimmune syndromes highlight the need to develop improved strategies to predict patient outcome to therapy and personalize patient care. Mass cytometry, using CyTOF®, is an advanced technology that facilitates multiparametric, phenotypic analysis of immune cells at single-cell resolution. In this review, we outline the capabilities of mass cytometry and illustrate the potential of this technology to enhance the discovery of cellular biomarkers for rheumatoid arthritis, a prototypical autoimmune disease. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 5% |
| Unknown | 109 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 40 | 35% |
| Student > Ph. D. Student | 16 | 14% |
| Student > Master | 10 | 9% |
| Student > Bachelor | 6 | 5% |
| Professor > Associate Professor | 6 | 5% |
| Other | 19 | 17% |
| Unknown | 18 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 25% |
| Medicine and Dentistry | 20 | 17% |
| Immunology and Microbiology | 16 | 14% |
| Biochemistry, Genetics and Molecular Biology | 10 | 9% |
| Computer Science | 4 | 3% |
| Other | 14 | 12% |
| Unknown | 22 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2022.
All research outputs
#7,047,002
of 25,371,288 outputs
Outputs from Arthritis Research & Therapy
#1,459
of 3,381 outputs
Outputs of similar age
#77,035
of 279,392 outputs
Outputs of similar age from Arthritis Research & Therapy
#30
of 64 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,392 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.