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Neuroanatomical Visualization of the Impaired Striatal Connectivity in Huntington’s Disease Mouse Model

Overview of attention for article published in Molecular Neurobiology, May 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

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1 news outlet
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Title
Neuroanatomical Visualization of the Impaired Striatal Connectivity in Huntington’s Disease Mouse Model
Published in
Molecular Neurobiology, May 2015
DOI 10.1007/s12035-015-9214-2
Pubmed ID
Authors

Dohee Kim, Jeha Jeon, Eunji Cheong, Dong Jin Kim, Hoon Ryu, Hyemyung Seo, Yun Kyung Kim

Abstract

Huntington's disease (HD) is a movement disorder characterized by the early selective degeneration of striatum. For motor control, the striatum receives excitatory inputs from multiple brain regions and projects the information to other basal ganglia nuclei. Despite the pathological importance of the striatal degeneration in HD, there are little anatomical data that show impaired striatal connectivity in HD. For the anatomical mapping of the striatum, we injected here a neurotracer DiD to the dorsal striatum of HD mouse model (YAC128). Compared with littermate controls, the number of the traced inputs to the striatum was reduced dramatically in YAC128 mice at 12 months of age suggesting massive destruction of the striatal connections. Basal ganglia inputs were significantly damaged in HD mice by showing 61 % decrease in substantia nigra pars compacta, 85 % decrease in thalamic centromedian nucleus, and 55 % decrease in thalamic parafascicular nucleus. Cortical inputs were also greatly decreased by 43 % in motor cortex, 48 % in somatosensory cortex, and 72 % in visual cortex. Besides the known striatal connections, the neurotracer DiD also traced inputs from amygdala and the amygdala inputs were decreased by 68 % in YAC128 mice. Considering the role of amygdala in emotion processing, the impairment in amygdalostriatal connectivity strongly suggests that emotional disturbances could occur in HD mice. Indeed, open-field tests further indicated that YAC128 mice exhibited changes in emotional behaviors related to symptoms of depression and anxiety. Although onset of HD is clinically determined on the basis of motor abnormality, emotional deficits are also common features of the disease. Therefore, our anatomical connectivity mapping of the striatum provides a new insight to interpret brain dysfunction in HD.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Colombia 1 3%
Unknown 30 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 25%
Student > Bachelor 6 19%
Student > Doctoral Student 2 6%
Student > Master 2 6%
Researcher 2 6%
Other 3 9%
Unknown 9 28%
Readers by discipline Count As %
Neuroscience 7 22%
Agricultural and Biological Sciences 5 16%
Psychology 3 9%
Biochemistry, Genetics and Molecular Biology 2 6%
Medicine and Dentistry 2 6%
Other 2 6%
Unknown 11 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2015.
All research outputs
#2,876,350
of 22,805,349 outputs
Outputs from Molecular Neurobiology
#428
of 3,449 outputs
Outputs of similar age
#38,857
of 264,751 outputs
Outputs of similar age from Molecular Neurobiology
#15
of 114 outputs
Altmetric has tracked 22,805,349 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,449 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,751 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 114 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.