| Title |
Alterations in default-mode network connectivity may be influenced by cerebrovascular changes within 1 week of sports related concussion in college varsity athletes: a pilot study
|
|---|---|
| Published in |
Brain Imaging and Behavior, May 2015
|
| DOI | 10.1007/s11682-015-9407-3 |
| Pubmed ID | |
| Authors |
Adam R. Militana, Manus J. Donahue, Allen K. Sills, Gary S. Solomon, Andrew J. Gregory, Megan K. Strother, Victoria L. Morgan |
| Abstract |
The goal of this pilot study is to use complementary MRI strategies to quantify and relate cerebrovascular reactivity, resting cerebral blood flow and functional connectivity alterations in the first week following sports concussion in college varsity athletes. Seven college athletes (3F/4M, age = 19.7 ± 1.2 years) were imaged 3-6 days following a diagnosed sports related concussion and compared to eleven healthy controls with no history of concussion (5M/6F, 18-23 years, 7 athletes). Cerebrovascular reactivity and functional connectivity were measured using functional MRI during a hypercapnia challenge and via resting-state regional partial correlations, respectively. Resting cerebral blood flow was quantified using arterial spin labeling MRI methods. Group comparisons were made within and between 18 regions of interest. Cerebrovascular reactivity was increased after concussion when averaged across all regions of interest (p = 0.04), and within some default-mode network regions, the anterior cingulate and the right thalamus (p < 0.05) independently. The FC was increased in the concussed athletes within the default-mode network including the left and right hippocampus, precuneus and ventromedial prefrontal cortex (p < 0.01), with measures being linearly related to cerebrovascular reactivity in the hippocampus in the concussed athletes. Significant resting cerebral blood flow changes were not detected between the two groups. This study provides evidence for increased cerebrovascular reactivity and functional connectivity in the medial regions of the default-mode network within days of a single sports related concussion in college athletes. Our findings emphasize the utility of complementary cerebrovascular measures in the interpretation of alterations in functional connectivity following concussion. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 118 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 22% |
| Student > Bachelor | 18 | 15% |
| Student > Master | 13 | 11% |
| Researcher | 12 | 10% |
| Other | 11 | 9% |
| Other | 21 | 18% |
| Unknown | 18 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 27 | 23% |
| Medicine and Dentistry | 26 | 22% |
| Psychology | 13 | 11% |
| Agricultural and Biological Sciences | 7 | 6% |
| Sports and Recreations | 6 | 5% |
| Other | 18 | 15% |
| Unknown | 22 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2015.
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#15,333,503
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Outputs from Brain Imaging and Behavior
#671
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#156,437
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Outputs of similar age from Brain Imaging and Behavior
#24
of 35 outputs
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