| Title |
Mathematical model of flagella gene expression dynamics in Salmonella enterica serovar typhimurium
|
|---|---|
| Published in |
Systems and Synthetic Biology, February 2015
|
| DOI | 10.1007/s11693-015-9160-3 |
| Pubmed ID | |
| Authors |
Kirti Jain, Amit Pradhan, Chaitanya Mokashi, Supreet Saini |
| Abstract |
Flagellar assembly in Salmonella is controlled by an intricate genetic and biochemical network. This network comprises of a number of inter-connected feedback loops, which control the assembly process dynamically. Critical among these are the FliA-FlgM feedback, FliZ-mediated positive feedback, and FliT-mediated negative feedback. In this work, we develop a mathematical model to track the dynamics of flagellar gene expression in Salmonella. Analysis of our model demonstrates that the network is wired to not only control the transition of the cell from a non-flagellated to a flagellated state, but to also control dynamics of gene expression during cell division. Further, we predict that FliZ encoded in the flagellar regulon acts as a critical secretion-dependent molecular link between flagella and Salmonella Pathogenicity Island 1 gene expression. Sensitivity analysis of the model demonstrates that the flagellar regulatory network architecture is extremely robust to mutations. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 20 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 30% |
| Researcher | 3 | 15% |
| Student > Master | 2 | 10% |
| Student > Doctoral Student | 1 | 5% |
| Lecturer > Senior Lecturer | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 5 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 35% |
| Agricultural and Biological Sciences | 5 | 25% |
| Medicine and Dentistry | 2 | 10% |
| Mathematics | 1 | 5% |
| Unknown | 5 | 25% |
Attention Score in Context
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#18,410,971
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Outputs from Systems and Synthetic Biology
#81
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#256,575
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Outputs of similar age from Systems and Synthetic Biology
#5
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