| Title |
Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial
|
|---|---|
| Published in |
Diabetologia, May 2015
|
| DOI | 10.1007/s00125-015-3610-z |
| Pubmed ID | |
| Authors |
The Look AHEAD Research Group |
| Abstract |
Both obesity and genetics contribute to cardiovascular disease (CVD). We examined whether a genetic risk score (GRS) prospectively predicted cardiovascular morbidity and mortality among overweight/obese individuals with type 2 diabetes and whether behavioural weight loss could diminish this association. Look AHEAD (Action for Health in Diabetes) is a randomised controlled trial to determine the effects of intensive lifestyle intervention (ILI), including weight loss and physical activity, relative to diabetes support and education, on cardiovascular outcomes among overweight/obese individuals with type 2 diabetes. Of the participants, 4,016 provided consent for genetic analyses and had DNA samples passing quality control procedures. These secondary data analyses focused on whether a GRS derived from 153 single nucleotide polymorphisms (SNPs) associated with coronary artery disease in the most recent genome-wide association study predicted cardiovascular morbidity and mortality over a median of 9.6 years of follow-up, and whether ILI would diminish this association. The GRS significantly predicted the primary composite endpoint of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalisation for angina in the full sample (HR, 95% CI per 1 SD increase in GRS: 1.19 [1.10, 1.28]) and among individuals with no known history of CVD at baseline (HR 1.18 [95% CI 1.07, 1.30]). In no case did ILI significantly alter this association. A GRS comprised of SNPs significantly predicts cardiovascular morbidity and mortality over 9.6 years of follow-up in Look AHEAD. Lifestyle intervention did not alter the genetic association. NCT00017953; NCT01270763. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
| Scientists | 1 | 33% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 178 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Unknown | 175 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 22 | 12% |
| Student > Bachelor | 22 | 12% |
| Researcher | 21 | 12% |
| Student > Ph. D. Student | 16 | 9% |
| Student > Postgraduate | 12 | 7% |
| Other | 22 | 12% |
| Unknown | 63 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 20% |
| Nursing and Health Professions | 22 | 12% |
| Agricultural and Biological Sciences | 12 | 7% |
| Biochemistry, Genetics and Molecular Biology | 10 | 6% |
| Sports and Recreations | 5 | 3% |
| Other | 14 | 8% |
| Unknown | 79 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2016.
All research outputs
#13,202,270
of 22,805,349 outputs
Outputs from Diabetologia
#4,173
of 5,035 outputs
Outputs of similar age
#123,151
of 264,461 outputs
Outputs of similar age from Diabetologia
#48
of 73 outputs
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