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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance
|
|---|---|
| Published in |
Cell Death & Disease, April 2018
|
| DOI | 10.1038/s41419-018-0542-9 |
| Pubmed ID | |
| Authors |
Bin Yan, Shuang Liu, Ying Shi, Na Liu, Ling Chen, Xiang Wang, Desheng Xiao, Xiaoli Liu, Chao Mao, Yiqun Jiang, Weiwei Lai, Xing Xin, Can-E Tang, Dixian Luo, Tan Tan, Jiantao Jia, Yating Liu, Rui Yang, Jun Huang, Hu Zhou, Yan Cheng, Ya Cao, Weishi Yu, Kathrin Muegge, Yongguang Tao |
| Abstract |
Most cancer patients receive radiotherapy in the course of their disease and the occurrence of radioresistance is associated with poor prognosis. The molecular pathways that drive enhanced tumorigenic potential during the development of radioresistance are poorly understood. Here, we demonstrate that aryl hydrocarbon receptor (AhR) plays a vital role in the maintenance of cancer stem-like properties. AhR promotes the cancer stem-like phenotype and drives metastasis by directly targeting the promoters of 'stemness' genes, such as the ATP-binding cassette sub-family G member 2 (ABCG2) gene. Moreover, the radioresistant sublines display high levels of oncometabolites including α-ketoglutarate, and treatment of cancer cells with α-ketoglutarate enhances their stem-like properties in an AhR activation-dependent manner. IKKα directly activates stemness-related genes through an interaction with AhR as a bone fide chromatin modifier. Thus, AhR is functionally linked with cancer stem-like properties, and it drives tumorigenesis in the occurrence of radioresistance. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 19% |
| Researcher | 5 | 16% |
| Student > Ph. D. Student | 3 | 9% |
| Student > Doctoral Student | 2 | 6% |
| Student > Postgraduate | 2 | 6% |
| Other | 5 | 16% |
| Unknown | 9 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 31% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 13% |
| Agricultural and Biological Sciences | 4 | 13% |
| Nursing and Health Professions | 3 | 9% |
| Medicine and Dentistry | 2 | 6% |
| Other | 0 | 0% |
| Unknown | 9 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2018.
All research outputs
#15,506,823
of 23,045,021 outputs
Outputs from Cell Death & Disease
#3,712
of 6,506 outputs
Outputs of similar age
#207,448
of 325,398 outputs
Outputs of similar age from Cell Death & Disease
#122
of 230 outputs
Altmetric has tracked 23,045,021 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,506 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,398 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 230 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.