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Attention Score in Context
| Title |
Identification of a novel FGFRL1 MicroRNA target site polymorphism for bone mineral density in meta-analyses of genome-wide association studies
|
|---|---|
| Published in |
Human Molecular Genetics, May 2015
|
| DOI | 10.1093/hmg/ddv144 |
| Pubmed ID | |
| Authors |
Tianhua Niu, Ning Liu, Ming Zhao, Guie Xie, Lei Zhang, Jian Li, Yu-Fang Pei, Hui Shen, Xiaoying Fu, Hao He, Shan Lu, Xiang-Ding Chen, Li-Jun Tan, Tie-Lin Yang, Yan Guo, Paul J. Leo, Emma L. Duncan, Jie Shen, Yan-Fang Guo, Geoffrey C. Nicholson, Richard L. Prince, John A. Eisman, Graeme Jones, Philip N. Sambrook, Xiang Hu, Partha M. Das, Qing Tian, Xue-Zhen Zhu, Christopher J. Papasian, Matthew A. Brown, André G. Uitterlinden, Yu-Ping Wang, Shuanglin Xiang, Hong-Wen Deng |
| Abstract |
MicroRNAs (miRNAs) are critical post-transcriptional regulators. Based on a previous genome-wide association (GWA) scan, we conducted a polymorphism in microRNAs' Target Sites (poly-miRTS)-centric multistage meta-analysis for lumbar spine (LS)-, total hip (HIP)-, and femoral neck (FN)-bone mineral density (BMD). In stage I, 41,102 poly-miRTSs were meta-analyzed in 7 cohorts with a genome-wide significance (GWS) α=0.05/41,102=1.22×10(-6). By applying α=5×10(-5) (suggestive significance), 11 poly-miRTSs were selected, with FGFRL1 rs4647940 and PRR5 rs3213550 as top signals for FN-BMD (P-value=7.67×10(-6) and 1.58×10(-5)) in gender-combined sample. In stage II in silico replication (two cohorts), FGFRL1 rs4647940 was the only signal marginally replicated for FN-BMD (P-value=5.08×10(-3)) at α=0.10/11=9.09×10(-3). PRR5 rs3213550 was also selected based on biological significance. In stage III de novo genotyping replication (two cohorts), FGFRL1 rs4647940 was the only signal significantly replicated for FN-BMD (P-value=7.55×10(-6)) at α=0.05/2=0.025 in gender-combined sample. Aggregating three stages, FGFRL1 rs4647940 was the single stage I-discovered and stages II- and III-replicated signal attaining GWS for FN-BMD (P-value=8.87×10(-12)). Dual-luciferase reporter assays demonstrated that FGFRL1 3' untranslated region harboring rs4647940 appears to be hsa-miR-140-5p's target site. In a zebrafish microinjection experiment, dre-miR-140-5p is shown to exert a dramatic impact on craniofacial skeleton formation. Taken together, we provided functional evidence for a novel FGFRL1 poly-miRTS rs4647940 in a previously known 4p16.3 locus, and experimental and clinical genetics studies have shown both FGFRL1 and hsa-miR-140-5p are important for bone formation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 19% |
| Student > Ph. D. Student | 5 | 12% |
| Student > Doctoral Student | 4 | 10% |
| Student > Master | 4 | 10% |
| Student > Bachelor | 3 | 7% |
| Other | 5 | 12% |
| Unknown | 13 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 24% |
| Medicine and Dentistry | 5 | 12% |
| Agricultural and Biological Sciences | 4 | 10% |
| Environmental Science | 1 | 2% |
| Psychology | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 18 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2015.
All research outputs
#20,273,512
of 22,805,349 outputs
Outputs from Human Molecular Genetics
#7,630
of 8,023 outputs
Outputs of similar age
#222,667
of 264,420 outputs
Outputs of similar age from Human Molecular Genetics
#100
of 111 outputs
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