Title |
Natural killer cell heterogeneity: cellular dysfunction and significance in HIV-1 immuno-pathogenesis
|
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Published in |
Cellular and Molecular Life Sciences, May 2015
|
DOI | 10.1007/s00018-015-1911-5 |
Pubmed ID | |
Authors |
A. Wahid Ansari, Fareed Ahmad, Dirk Meyer-Olson, Adeeba Kamarulzaman, Roland Jacobs, Reinhold E. Schmidt |
Abstract |
Natural killer (NK) cells are innate immune effectors that provide first line of defence against viruses. Human NK cells are heterogeneous in nature, and their functions rely on a dynamic balance between germ-line-encoded activating and inhibitory receptors. HIV-1 infection results in altered NK cell receptor repertoire and impaired effector functions including the ability to lyse virus-infected cells and secretion of antiviral cytokine IFN-γ. Over the last decade, additional NK cell subset-specific molecules have been identified, leading to emergence of a more complex cellular diversity than previously thought. Herein, we discuss NK cell subset redistribution, altered receptor repertoire and influence of interaction of polymorphic leucocyte antigen (HLA) and killer cell immunoglobulin-like receptors (KIR) on HIV-1 disease progression. |
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Unknown | 2 | 100% |
Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Denmark | 1 | 3% |
Unknown | 35 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 22% |
Researcher | 6 | 17% |
Student > Doctoral Student | 5 | 14% |
Student > Postgraduate | 4 | 11% |
Student > Master | 3 | 8% |
Other | 7 | 19% |
Unknown | 3 | 8% |
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Agricultural and Biological Sciences | 7 | 19% |
Immunology and Microbiology | 6 | 17% |
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Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 2 | 6% |
Unknown | 7 | 19% |