Title |
A breakthrough in probiotics: Clostridium butyricum regulates gut homeostasis and anti-inflammatory response in inflammatory bowel disease
|
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Published in |
Journal of Gastroenterology, May 2015
|
DOI | 10.1007/s00535-015-1084-x |
Pubmed ID | |
Authors |
Takanori Kanai, Yohei Mikami, Atsushi Hayashi |
Abstract |
Intestinal immune homeostasis is regulated by gut microbiota, including beneficial and pathogenic microorganisms. Imbalance in gut bacterial constituents provokes host proinflammatory responses causing diseases such as inflammatory bowel disease (IBD). The development of next-generation sequencing technology allows the identification of microbiota alterations in IBD. Several studies have shown reduced diversity in the gut microbiota of patients with IBD. Advances in gnotobiotic technology have made possible analysis of the role of specific bacterial strains in immune cells in the intestine. Using these techniques, we have shown that Clostridium butyricum as a probiotic induces interleukin-10-producing macrophages in inflamed mucosa via the Toll-like receptor 2/myeloid differentiation primary response gene 88 pathway to prevent acute experimental colitis. In this review, we focus on the new approaches for the role of specific bacterial strains in immunological responses, as well as the potential of bacterial therapy for IBD treatments. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
Ireland | 1 | <1% |
France | 1 | <1% |
Unknown | 120 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 23 | 19% |
Student > Ph. D. Student | 20 | 16% |
Student > Master | 11 | 9% |
Student > Bachelor | 9 | 7% |
Student > Doctoral Student | 6 | 5% |
Other | 19 | 15% |
Unknown | 35 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 22 | 18% |
Agricultural and Biological Sciences | 18 | 15% |
Medicine and Dentistry | 14 | 11% |
Immunology and Microbiology | 13 | 11% |
Engineering | 3 | 2% |
Other | 11 | 9% |
Unknown | 42 | 34% |