| Title |
Allosteric function and dysfunction of the prion protein
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, October 2011
|
| DOI | 10.1007/s00018-011-0847-7 |
| Pubmed ID | |
| Authors |
Rafael Linden, Yraima Cordeiro, Luis Mauricio T. R. Lima |
| Abstract |
Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases associated with progressive oligo- and multimerization of the prion protein (PrP(C)), its conformational conversion, aggregation and precipitation. We recently proposed that PrP(C) serves as a cell surface scaffold protein for a variety of signaling modules, the effects of which translate into wide-range functional consequences. Here we review evidence for allosteric functions of PrP(C), which constitute a common property of scaffold proteins. The available data suggest that allosteric effects among PrP(C) and its partners are involved in the assembly of multi-component signaling modules at the cell surface, impose upon both physiological and pathological conformational responses of PrP(C), and that allosteric dysfunction of PrP(C) has the potential to entail progressive signal corruption. These properties may be germane both to physiological roles of PrP(C), as well as to the pathogenesis of the TSEs and other degenerative/non-communicable diseases. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Malaysia | 1 | 2% |
| Spain | 1 | 2% |
| France | 1 | 2% |
| Unknown | 61 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 22% |
| Student > Ph. D. Student | 13 | 20% |
| Student > Bachelor | 10 | 16% |
| Student > Master | 6 | 9% |
| Professor | 5 | 8% |
| Other | 12 | 19% |
| Unknown | 4 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 36% |
| Biochemistry, Genetics and Molecular Biology | 14 | 22% |
| Neuroscience | 9 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
| Medicine and Dentistry | 4 | 6% |
| Other | 5 | 8% |
| Unknown | 4 | 6% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2011.
All research outputs
#15,492,086
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#2,969
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Outputs of similar age
#94,500
of 138,399 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#32
of 40 outputs
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