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Stem Cell Biology in Neoplasms of the Central Nervous System

Overview of attention for book
Attention for Chapter 7: Chemoresistance and chemotherapy targeting stem-like cells in malignant glioma.
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Chapter title
Chemoresistance and chemotherapy targeting stem-like cells in malignant glioma.
Chapter number 7
Book title
Stem Cell Biology in Neoplasms of the Central Nervous System
Published in
Advances in experimental medicine and biology, January 2015
DOI 10.1007/978-3-319-16537-0_7
Pubmed ID
Book ISBNs
978-3-31-916536-3, 978-3-31-916537-0
Authors

Sørensen, Mia Dahl, Fosmark, Sigurd, Hellwege, Sofie, Beier, Dagmar, Kristensen, Bjarne Winther, Beier, Christoph Patrick, Mia Dahl Sørensen, Sigurd Fosmark, Sofie Hellwege, Dagmar Beier, Bjarne Winther Kristensen, Christoph Patrick Beier

Abstract

Glioblastoma remains a tumor with a dismal prognosis because of failure of current treatment. Glioblastoma cells with stem cell (GSC) properties survive chemotherapy and give rise to tumor recurrences that invariably result in the death of the patients. Here we summarize the current knowledge on chemoresistance of malignant glioma with a strong focus on GSC. Chemoresistant GSC are the most likely cause of tumor recurrence, but it remains controversial if GSC and under which conditions GSC are more chemoresistant than non-GSC within the tumor. Regardless of this uncertainty, the chemoresistance varies and it is mainly mediated by intrinsic factors. O6-methyl-guanidine methyltransferase (MGMT) remains the most potent mediator of chemoresistance, but disturbed mismatch repair system and multidrug resistance proteins contribute substantially. However, the intrinsic resistance by MGMT expression is regulated by extrinsic factors like hypoxia increasing MGMT expression and thereby resistance to alkylating chemotherapy. The search of new biomarkers helping to predict the tumor response to chemotherapy is ongoing and will complement the already known markers like MGMT.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 26%
Student > Ph. D. Student 4 11%
Researcher 4 11%
Student > Doctoral Student 3 9%
Student > Master 2 6%
Other 6 17%
Unknown 7 20%
Readers by discipline Count As %
Medicine and Dentistry 9 26%
Biochemistry, Genetics and Molecular Biology 6 17%
Agricultural and Biological Sciences 4 11%
Neuroscience 4 11%
Engineering 2 6%
Other 2 6%
Unknown 8 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2015.
All research outputs
#20,273,512
of 22,805,349 outputs
Outputs from Advances in experimental medicine and biology
#3,967
of 4,950 outputs
Outputs of similar age
#295,802
of 353,075 outputs
Outputs of similar age from Advances in experimental medicine and biology
#189
of 272 outputs
Altmetric has tracked 22,805,349 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,950 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,075 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 272 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.