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Stem Cell Biology in Neoplasms of the Central Nervous System

Overview of attention for book
Attention for Chapter 9: Emerging strategies for the treatment of tumor stem cells in central nervous system malignancies.
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Chapter title
Emerging strategies for the treatment of tumor stem cells in central nervous system malignancies.
Chapter number 9
Book title
Stem Cell Biology in Neoplasms of the Central Nervous System
Published in
Advances in experimental medicine and biology, January 2015
DOI 10.1007/978-3-319-16537-0_9
Pubmed ID
Book ISBNs
978-3-31-916536-3, 978-3-31-916537-0
Authors

Khan, Imad Saeed, Ehtesham, Moneeb, Imad Saeed Khan, Moneeb Ehtesham

Abstract

High-grade central nervous system (CNS) tumors are notorious for high rates of recurrence and poor outcomes. A small cohort of tumor cells, dubbed tumor stem cells (TSC), are now being recognized as an important subset of the tumor that is resistant to chemotherapy and radiotherapy and account for the high recurrence rates. Recent research is developing modalities to target TSCs specifically in a bid to improve the response of the tumor as a whole. The methods being employed to target TSCs include targeting TSC-specific pathways or receptors, TSC-sensitizing agents to chemotherapy and radiotherapy, immunotherapy, TSC-differentiating agents, and viral therapy. This chapter provides an overview of strategies that are expected to help develop new and more effective treatments for CNS tumors.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 17%
Researcher 2 17%
Student > Bachelor 1 8%
Lecturer 1 8%
Student > Master 1 8%
Other 1 8%
Unknown 4 33%
Readers by discipline Count As %
Medicine and Dentistry 4 33%
Neuroscience 2 17%
Nursing and Health Professions 1 8%
Unknown 5 42%