Chapter title |
Emerging strategies for the treatment of tumor stem cells in central nervous system malignancies.
|
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Chapter number | 9 |
Book title |
Stem Cell Biology in Neoplasms of the Central Nervous System
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Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-3-319-16537-0_9 |
Pubmed ID | |
Book ISBNs |
978-3-31-916536-3, 978-3-31-916537-0
|
Authors |
Khan, Imad Saeed, Ehtesham, Moneeb, Imad Saeed Khan, Moneeb Ehtesham |
Abstract |
High-grade central nervous system (CNS) tumors are notorious for high rates of recurrence and poor outcomes. A small cohort of tumor cells, dubbed tumor stem cells (TSC), are now being recognized as an important subset of the tumor that is resistant to chemotherapy and radiotherapy and account for the high recurrence rates. Recent research is developing modalities to target TSCs specifically in a bid to improve the response of the tumor as a whole. The methods being employed to target TSCs include targeting TSC-specific pathways or receptors, TSC-sensitizing agents to chemotherapy and radiotherapy, immunotherapy, TSC-differentiating agents, and viral therapy. This chapter provides an overview of strategies that are expected to help develop new and more effective treatments for CNS tumors. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 2 | 17% |
Researcher | 2 | 17% |
Student > Bachelor | 1 | 8% |
Lecturer | 1 | 8% |
Student > Master | 1 | 8% |
Other | 1 | 8% |
Unknown | 4 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 33% |
Neuroscience | 2 | 17% |
Nursing and Health Professions | 1 | 8% |
Unknown | 5 | 42% |