| Title |
Clinicopathological Meaning of Size of Main‐Duct Dilatation in Intraductal Papillary Mucinous Neoplasm of Pancreas: Proposal of a Simplified Morphological Classification Based on the Investigation on the Size of Main Pancreatic Duct
|
|---|---|
| Published in |
World Journal of Surgery, April 2015
|
| DOI | 10.1007/s00268-015-3062-0 |
| Pubmed ID | |
| Authors |
Mee Joo Kang, Jin‐Young Jang, Selyeong Lee, Taesung Park, Seung Yeoun Lee, Sun‐Whe Kim |
| Abstract |
The 2012 consensus guideline on intraductal papillary mucinous neoplasm of the pancreas (IPMN) described a three-stage criteria involving main pancreatic duct (MPD) size with definitions of malignancy relevant for treatment decisions. Re-evaluation and simplification of this classification for clinicians are warranted. Data from the Seoul National University Hospital of 375 consecutive patients with pathology-confirmed IPMN after surgery were analyzed. The association between clinicopathologic characteristics of IPMN and MPD size was assessed. The cut-off value of MPD size for a current definition of malignancy prediction was calculated. Diagnostic accuracy for malignancy was highest when the cut-off value of MPD size was 7 mm (area under the curve = 0.7126). Dichotomizing IPMN into MPD ≤7 mm versus MPD >7 mm, patient age (p = 0.039), sex (p = 0.001), presence of mural nodule (p < 0.001), and invasiveness risk (13.2 vs. 39.8 %, p < 0.001) resulted in significantly different results. Mural nodule-negative patients with MPD >7 mm had a significantly lower 5-year survival rate than those with MPD ≤7 mm (78.4 vs. 91.4 %, p = 0.006). Among patients with MPD size ≤7 mm, elevated serum CA 19-9 and mural nodule were independent risk factors of malignancy. Patients with MPD size ≤7 mm without these risk factors had malignancy risk of 2.6 %. Using the definition of malignancy provided in the 2012 guideline, the MPD size >7 mm criterion was statistically driven. The current morphologic classification of IPMN can be simplified as branch-duct-predominant IPMN (MPD ≤7 mm)' and main-duct-predominant IPMN (MPD >7 mm). Patients who are determined to have main-duct-predominant IPMN and branch-duct-predominant IPMN with elevated serum CA 19-9 or mural nodule are recommended to undergo surgical treatment. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 16% |
| Student > Doctoral Student | 4 | 11% |
| Student > Ph. D. Student | 3 | 8% |
| Other | 2 | 5% |
| Lecturer | 2 | 5% |
| Other | 9 | 24% |
| Unknown | 11 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 49% |
| Unspecified | 1 | 3% |
| Nursing and Health Professions | 1 | 3% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Earth and Planetary Sciences | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 14 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2015.
All research outputs
#20,273,512
of 22,805,349 outputs
Outputs from World Journal of Surgery
#3,793
of 4,229 outputs
Outputs of similar age
#223,637
of 264,844 outputs
Outputs of similar age from World Journal of Surgery
#26
of 46 outputs
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