Title |
Predictors of outcome in patients undergoing MitraClip implantation: An aid to improve patient selection
|
---|---|
Published in |
International Journal of Cardiology, January 2015
|
DOI | 10.1016/j.ijcard.2015.01.045 |
Pubmed ID | |
Authors |
Kirsten Boerlage-vanDijk, Esther M.A. Wiegerinck, Motoharu Araki, Paola G. Meregalli, Navin R. Bindraban, Karel T. Koch, M. Marije Vis, Jan J. Piek, Jan G.P. Tijssen, Berto J. Bouma, Jan Baan |
Abstract |
MitraClip implantation (MCI) reduces mitral regurgitation (MR) and symptoms in patients considered inoperable or with high-surgical risk. Data to determine the benefit from MCI for an individual patient are limited. The aim of this study is to determine predictors associated with the prognosis after MCI to improve the patient selection for this procedure. We included 84 consecutive patients (age: 76±10years, 51% male) who underwent MCI in our institution for symptomatic severe MR. All patients underwent transthoracic echocardiography before MCI; clinical and echocardiographic follow-up was obtained after MCI. The 2-year survival was 81%. Predictors for two-year mortality in multi-variate analysis were baseline NT-proBNP≥5000μg/L (HR: 5.4, 95% CI: 1.8-16.2), previous valve surgery (HR: 4.5, 95% CI: 1.7-12.2), tricuspid regurgitation (TR)≥grade 3 prior to MCI (HR: 2.8, 95% CI: 1.2-6.8) and absence of MR reduction after MCI (HR: 2.1, 95% CI: 1.2-3.8). The 2-year survival of patients with 0, 1 or ≥2 of these predictors was: 87%; 78% and 38% respectively (log-rank p<0.001). The functional class at 1month and mid-term follow-up was worse in patients with two or more of these predictors present at baseline compared to patients with zero or one of these predictors (1month: p=0.007 and mid-term: p<0.001). Heart failure, previous valve surgery, co-presence of TR and the degree of MR reduction after MCI are the independent predictors of survival and functional status after MCI in high risk patients. The pre-procedural characteristics may be used to optimize patient selection, while maximal MR reduction should be attempted to optimize the outcome of MCI. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 53 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 21% |
Student > Doctoral Student | 9 | 17% |
Student > Bachelor | 8 | 15% |
Student > Postgraduate | 5 | 9% |
Other | 4 | 8% |
Other | 7 | 13% |
Unknown | 9 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 35 | 66% |
Psychology | 1 | 2% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Neuroscience | 1 | 2% |
Engineering | 1 | 2% |
Other | 0 | 0% |
Unknown | 14 | 26% |