| Title |
Relating structure and function of inner hair cell ribbon synapses
|
|---|---|
| Published in |
Cell and Tissue Research, January 2015
|
| DOI | 10.1007/s00441-014-2102-7 |
| Pubmed ID | |
| Authors |
C. Wichmann, T. Moser |
| Abstract |
In the mammalian cochlea, sound is encoded at synapses between inner hair cells (IHCs) and type I spiral ganglion neurons (SGNs). Each SGN receives input from a single IHC ribbon-type active zone (AZ) and yet SGNs indefatigably spike up to hundreds of Hz to encode acoustic stimuli with submillisecond precision. Accumulating evidence indicates a highly specialized molecular composition and structure of the presynapse, adapted to suit these high functional demands. However, we are only beginning to understand key features such as stimulus-secretion coupling, exocytosis mechanisms, exo-endocytosis coupling, modes of endocytosis and vesicle reformation, as well as replenishment of the readily releasable pool. Relating structure and function has become an important avenue in addressing these points and has been applied to normal and genetically manipulated hair cell synapses. Here, we review some of the exciting new insights gained from recent studies of the molecular anatomy and physiology of IHC ribbon synapses. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 160 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Germany | 2 | 1% |
| Switzerland | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 154 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 22% |
| Researcher | 25 | 16% |
| Student > Master | 16 | 10% |
| Student > Bachelor | 15 | 9% |
| Other | 10 | 6% |
| Other | 30 | 19% |
| Unknown | 29 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 41 | 26% |
| Agricultural and Biological Sciences | 26 | 16% |
| Biochemistry, Genetics and Molecular Biology | 23 | 14% |
| Medicine and Dentistry | 18 | 11% |
| Nursing and Health Professions | 4 | 3% |
| Other | 15 | 9% |
| Unknown | 33 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2015.
All research outputs
#6,769,594
of 23,839,820 outputs
Outputs from Cell and Tissue Research
#418
of 2,279 outputs
Outputs of similar age
#90,732
of 356,452 outputs
Outputs of similar age from Cell and Tissue Research
#7
of 40 outputs
Altmetric has tracked 23,839,820 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 2,279 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 356,452 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.