Title |
Molecular basis of oxidative stress in gouty arthropathy
|
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Published in |
Clinical Rheumatology, April 2015
|
DOI | 10.1007/s10067-015-2933-y |
Pubmed ID | |
Authors |
Yessica Zamudio-Cuevas, Cristina Hernández-Díaz, Carlos Pineda, Anthony M. Reginato, Jorge Francisco Cerna-Cortés, Lucio Ventura-Ríos, Alberto López-Reyes |
Abstract |
Gout is a disorder of urate metabolism in which persistent high urate levels in the extracellular fluids result in the deposition of monosodium urate (MSU) crystal in joints and periarticular tissues. In recent years, this disease represents an increasingly common health problem, so the pace of investigation in the field has accelerated tremendously. New research advances in the pathogenesis of hyperuricemia and in the understanding of how MSU crystals induce an acute gouty attack have been focused in this review on the processes of inflammation and involvement of the innate immune response; in addition, we discuss new knowledge about the role of the reactive oxygen species in establishing oxidative stress in MSU crystal-induced arthritis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 55 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 7 | 13% |
Student > Bachelor | 7 | 13% |
Researcher | 6 | 11% |
Student > Doctoral Student | 5 | 9% |
Student > Ph. D. Student | 5 | 9% |
Other | 9 | 16% |
Unknown | 16 | 29% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 5 | 9% |
Agricultural and Biological Sciences | 5 | 9% |
Nursing and Health Professions | 3 | 5% |
Other | 6 | 11% |
Unknown | 19 | 35% |