Title |
Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12
|
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Published in |
Tumor Biology, April 2015
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DOI | 10.1007/s13277-015-3340-3 |
Pubmed ID | |
Authors |
Zongtao Xie, Liming Cai, Runsheng Li, Jinyu Zheng, Hongyan Wu, Xiaoqi Yang, Hu Li, Zhiqiang Wang |
Abstract |
microRNAs are small, non-coding RNAs that contribute into various biological processes during cancer progression. However, the potential role of miR-489 in the development of Non-Small Cell Lung Cancer (NSCLC) is not demonstrated. In present study, miR-489 was down-regulated both in tumor tissues and cells. Inhibition of miR-489 promoted cells invasion by using an invasion assay. Furthermore, miR-489 could regulate SUZ12 as shown by luciferase reporter and Western blot assays. Aberrant miR-489 expression could regulate the molecular changes (E-cadherin, N-cadherin, and Vimentin) of epithelial mesenchymal transition (EMT). In conclusion, our study revealed that miR-489 may play an essential role in the progression of NSCLC. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 30% |
Researcher | 3 | 30% |
Student > Bachelor | 1 | 10% |
Student > Master | 1 | 10% |
Unknown | 2 | 20% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 40% |
Biochemistry, Genetics and Molecular Biology | 3 | 30% |
Agricultural and Biological Sciences | 1 | 10% |
Unknown | 2 | 20% |