Title |
Cohort Profile: The Barwon Infant Study
|
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Published in |
International Journal of Epidemiology, March 2015
|
DOI | 10.1093/ije/dyv026 |
Pubmed ID | |
Authors |
Peter Vuillermin, Richard Saffery, Katrina J Allen, John B Carlin, Mimi LK Tang, Sarath Ranganathan, David Burgner, Terry Dwyer, Fiona Collier, Kim Jachno, Peter Sly, Christos Symeonides, Kathleen McCloskey, John Molloy, Michael Forrester, Anne-Louise Ponsonby |
Abstract |
The modern environment is associated with an increasing burden of non-communicable diseases (NCDs). Mounting evidence implicates environmental exposures, experienced early in life (including in utero), in the aetiology of many NCDs, though the cellular/molecular mechanism(s) underlying this elevated risk across the life course remain unclear. Epigenetic variation has emerged as a candidate mediator of such effects. The Barwon Infant Study (BIS) is a population-derived birth cohort study (n = 1074 infants) with antenatal recruitment, conducted in the south-east of Australia (Victoria). BIS has been designed to facilitate a detailed mechanistic investigation of development within an epidemiological framework. The broad objectives are to investigate the role of specific environmental factors, gut microbiota and epigenetic variation in early-life development, and subsequent immune, allergic, cardiovascular, respiratory and neurodevelopmental outcomes. Participants have been reviewed at birth and at 1, 6, 9 and 12 months, with 2- and 4-year reviews under way. Biological samples and measures include: maternal blood, faeces and urine during pregnancy; infant urine, faeces and blood at regular intervals during the first 4 years; lung function at 1 month and 4 years; cardiovascular assessment at 1 month and 4 years; skin-prick allergy testing and food challenge at 1 year; and neurodevelopmental assessment at 9 months, 2 and 4 years. Data access enquiries can be made at [www.barwoninfantstudy.org.au] or via [[email protected]]. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
France | 1 | <1% |
Unknown | 117 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 19 | 16% |
Student > Ph. D. Student | 17 | 14% |
Researcher | 13 | 11% |
Student > Bachelor | 8 | 7% |
Student > Postgraduate | 7 | 6% |
Other | 20 | 17% |
Unknown | 35 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 24% |
Agricultural and Biological Sciences | 9 | 8% |
Immunology and Microbiology | 7 | 6% |
Biochemistry, Genetics and Molecular Biology | 6 | 5% |
Nursing and Health Professions | 4 | 3% |
Other | 19 | 16% |
Unknown | 46 | 39% |