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Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

news
1 news outlet

Citations

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73 Dimensions

Readers on

mendeley
66 Mendeley
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Title
Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel
Published in
Proceedings of the National Academy of Sciences of the United States of America, April 2015
DOI 10.1073/pnas.1503488112
Pubmed ID
Authors

Sara I Liin, Malin Silverå Ejneby, Rene Barro-Soria, Mark Alexander Skarsfeldt, Johan E Larsson, Frida Starck Härlin, Teija Parkkari, Bo Hjorth Bentzen, Nicole Schmitt, H Peter Larsson, Fredrik Elinder

Abstract

Polyunsaturated fatty acids (PUFAs) affect cardiac excitability. Kv7.1 and the β-subunit KCNE1 form the cardiac IKs channel that is central for cardiac repolarization. In this study, we explore the prospects of PUFAs as IKs channel modulators. We report that PUFAs open Kv7.1 via an electrostatic mechanism. Both the polyunsaturated acyl tail and the negatively charged carboxyl head group are required for PUFAs to open Kv7.1. We further show that KCNE1 coexpression abolishes the PUFA effect on Kv7.1 by promoting PUFA protonation. PUFA analogs with a decreased pKa value, to preserve their negative charge at neutral pH, restore the sensitivity to open IKs channels. PUFA analogs with a positively charged head group inhibit IKs channels. These different PUFA analogs could be developed into drugs to treat cardiac arrhythmias. In support of this possibility, we show that PUFA analogs act antiarrhythmically in embryonic rat cardiomyocytes and in isolated perfused hearts from guinea pig.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Germany 1 2%
Unknown 64 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 20%
Researcher 9 14%
Professor 7 11%
Other 6 9%
Student > Ph. D. Student 6 9%
Other 13 20%
Unknown 12 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 27%
Medicine and Dentistry 11 17%
Pharmacology, Toxicology and Pharmaceutical Science 9 14%
Agricultural and Biological Sciences 5 8%
Neuroscience 4 6%
Other 4 6%
Unknown 15 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2015.
All research outputs
#4,640,360
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#44,073
of 101,438 outputs
Outputs of similar age
#55,035
of 270,273 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#540
of 932 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,273 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 932 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.