| Title |
Acute and subchronic effects on immune responses of carp (Cyprinus carpio L.) after exposure to deoxynivalenol (DON) in feed
|
|---|---|
| Published in |
Mycotoxin Research, May 2015
|
| DOI | 10.1007/s12550-015-0226-6 |
| Pubmed ID | |
| Authors |
Constanze Pietsch, Barbara A. Katzenback, Erick Garcia-Garcia, Carsten Schulz, Miodrag Belosevic, Patricia Burkhardt-Holm |
| Abstract |
The mycotoxin deoxynivalenol (DON) has been shown to regularly occur at relevant concentrations in feed designed for aquaculture use, but little is known about the consequences of its presence on the organisms that consume the DON-contaminated feed. Previous studies indicated a down-regulation of pro-inflammatory responses in carp (Cyprinus carpio L.) after 4 weeks of feeding DON. The present study examined the time course of innate immune responses of carp to orally administered DON. Changes in mRNA levels of immune genes in different organs (head kidney, trunk kidney, spleen, liver, and intestine) were observed indicating immune-modulating properties of DON. The immune-modulatory effects during the acute phase of DON exposure were characterized by the activation of both pro- and anti-inflammatory cytokines and enzymes in carp. The subchronic responses to DON were characterized by activation of arginases culminating in increased arginase activity in head kidney leukocytes after 26 days of DON treatment. These results suggest profound effects of this mycotoxin on fish in aquaculture. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 20% |
| Researcher | 5 | 17% |
| Student > Master | 4 | 13% |
| Professor > Associate Professor | 2 | 7% |
| Professor | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 9 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 33% |
| Veterinary Science and Veterinary Medicine | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Immunology and Microbiology | 2 | 7% |
| Nursing and Health Professions | 1 | 3% |
| Other | 2 | 7% |
| Unknown | 11 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2016.
All research outputs
#20,273,512
of 22,805,349 outputs
Outputs from Mycotoxin Research
#217
of 237 outputs
Outputs of similar age
#223,312
of 266,745 outputs
Outputs of similar age from Mycotoxin Research
#3
of 4 outputs
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